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首页> 外文期刊>EFSA Journal >Statistical re‐analysis of the Biel maze data of the Stump et al (2010) study: “Developmental neurotoxicity study of dietary bisphenol A in Sprague‐Dawley rats”
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Statistical re‐analysis of the Biel maze data of the Stump et al (2010) study: “Developmental neurotoxicity study of dietary bisphenol A in Sprague‐Dawley rats”

机译：Stump等人（2010年）研究的Biel迷宫数据的统计重新分析：“饮食中双酚A对Sprague-Dawley大鼠的发育性神经毒性研究”

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The Biel maze data presented by Stump et al . (2010) were reanalysed by EFSA using statistical methods that took the censoring into consideration along with key experimental and design features. The results showed that it cannot be concluded that there is equivalence between the control group and BPA for neurotoxicity variables (i.e. time to escape and number of errors). Hence, statistically, the possibility of an effect of BPA on the neurotoxicity variables can neither be confirmed nor ruled out. After accounting for key design elements in the modelling there is still large variation in the hazard ratios for the dose effect. This indicates that the Biel maze test as performed by Stump et al . (2010) does not have the potential to demonstrate equivalence of BPA compared to a control. Therefore this study should be considered as being inconclusive.
机译：Stump等人提供的Biel迷宫数据。 （2010）由EFSA使用统计方法进行了重新分析，该方法考虑了审查以及关键的实验和设计特征。结果表明，不能得出结论，对照组和BPA在神经毒性变量（即逃脱时间和错误数量）上是等效的。因此，从统计学上讲，既不能确定也不排除BPA对神经毒性变量的影响。在考虑了建模中的关键设计要素之后，剂量效应的危害比仍然存在很大差异。这表明由Stump等人进行的Biel迷宫测试。 （2010年）没有潜力证明BPA与对照组相当。因此，该研究应被认为是非结论性的。

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