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首页> 外文期刊>Egyptian Journal of Basic and Applied Sciences >Isolation, structure characterization and prediction of antioxidant activity of two new compounds from the leaves of Dodonaea viscosa native to the Sultanate of Oman
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Isolation, structure characterization and prediction of antioxidant activity of two new compounds from the leaves of Dodonaea viscosa native to the Sultanate of Oman

机译：阿曼苏丹国天然 Dodonaea viscosa 叶片中两种新化合物的分离，结构表征和抗氧化活性预测

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Traditionally,Dodonaea viscosa(D. viscosa) is used worldwide for the treatment of different chronic diseases. The current investigation involves the isolation, structure characterization and prediction of antioxidant compounds from the leaves ofD. viscosa, which was collected from AL-Hamra, Sultanate of Oman. The leaves samples were used for the extraction of plant constituents with methanol by using hot extraction method. The methanol solvent was evaporated by usual method and the crude extract was dissolved in water and fractionation successively with different polarity solvents to give hexane, chloroform, ethyl acetate, butanol and water extracts, respectively. The antioxidant activity of different polarity crude extracts and isolated pure compounds was determined by modified 1,1-diphenyl-2-picryl-hydrazyl (DPPH) method. The highest antioxidant activity was found in hexane extract and the lowest antioxidant activity was found in butanol extract and followed by hexane?>?chloroform?>?ethyl acetate?>?methanol?>?water?>?butanol extract. The hexane and ethyl acetate crude extracts were used for the isolation and separation of antioxidant compounds by using different chromatographic techniques. The isolated pure compounds were characterized as 3,3′,4′,5,7-pentahydroxyflavane (1) and 4-methoxylstigmasterol (2) by MS,1H NMR,13C NMR, and 2D NMR. Both the compounds, 3,3′,4′,5,7-pentahydroxyflavane (1) and 4-methoxylstigmasterol (2) were isolated for the first time from the selected Omani plant species. The pure compounds obtained from hexane and ethyl acetate extracts of the selected plant species could be a good source of natural antioxidant.
机译：传统上，Dodonaea viscosa（D。viscosa）在世界范围内用于治疗各种慢性疾病。目前的研究涉及从D叶中分离，结构表征和预测抗氧化剂化合物。粘胶，从阿曼苏丹国AL-Hamra收集。叶样品用于通过热提取方法用甲醇提取植物成分。通过常规方法蒸发甲醇溶剂，并将粗提取物溶解于水中，并用不同极性的溶剂相继分馏，分别得到己烷，氯仿，乙酸乙酯，丁醇和水提取物。采用改进的1，1-二苯基-2-吡啶-2-肼基（DPPH）法测定了不同极性粗提物和分离出的纯化合物的抗氧化活性。在己烷提取物中发现最高的抗氧化剂活性，在丁醇提取物中发现最低的抗氧化剂活性，然后依次是己烷→＞氯仿→＞乙酸乙酯＞＞甲醇＞＞水＞＞→丁醇提取物。使用不同的色谱技术，将己烷和乙酸乙酯的粗提液用于抗氧化剂的分离和分离。分离的纯化合物通过MS，1 H NMR，13 C NMR和2D NMR表征为3,3'，4'，5,7-五羟基黄烷（1）和4-甲氧基豆甾醇（2）。首次从选定的阿曼植物物种中分离出3,3'，4'，5,7-五羟基黄烷酮（1）和4-甲氧基lstigmasterol（2）这两种化合物。从选定植物物种的己烷和乙酸乙酯提取物中获得的纯化合物可能是天然抗氧化剂的良好来源。

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