Strategies for appropriate antibiotic use in intensive care unit

Camila Delfino Ribeiro Da Silva; Moacyr Silva Júnior

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Strategies for appropriate antibiotic use in intensive care unit

机译：重症监护病房合理使用抗生素的策略

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The comsumption of antibiotics is high, mainly in intensive care units. Unfortunately, most are inappropriately used leading to increased multi-resistant bacteria. It is well known that initial empirical therapy with broad-spectrum antibiotics reduce mortality rates. However the prolonged and irrational use of antimicrobials may also increase the risk of toxicity, drug interactions and diarrhea due to Clostridium difficile. Some strategies to rational use of antimicrobial agents include avoiding colonization treatment, de-escalation, monitoring serum levels of the agents, appropriate duration of therapy and use of biological markers. This review discusses the effectiveness of these strategies, the importance of microbiology knowledge, considering there are agents resistant to Staphylococcus aureus andKlebsiella pneumoniae, and reducing antibiotic use and bacterial resistance, with no impact on mortality.

机译：抗生素的消费量很高，主要在重症监护病房。不幸的是，大多数使用不当会导致多重耐药菌增加。众所周知，使用广谱抗生素的初步经验疗法可降低死亡率。然而，由于艰难梭菌，长期和不合理使用抗菌药物也可能增加毒性，药物相互作用和腹泻的风险。合理使用抗微生物剂的一些策略包括避免定植治疗，降级，监测药物的血清水平，适当的治疗时间和使用生物标志物。这篇综述讨论了这些策略的有效性，微生物学知识的重要性，考虑到存在对金黄色葡萄球菌和肺炎克雷伯菌具有耐药性的药物，并减少抗生素的使用和细菌耐药性，而对死亡率没有影响。

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《Einstein (So Paulo)》 |2015年第3期|共6页
作者
Camila Delfino Ribeiro Da Silva; Moacyr Silva Júnior;
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中图分类预防医学、卫生学;
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Strategies for appropriate antibiotic use in intensive care unit

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