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Lung transplantation

机译：肺移植

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ABSTRACT Lung transplantation is a globally accepted treatment for some advanced lung diseases, giving the recipients longer survival and better quality of life. Since the first transplant successfully performed in 1983, more than 40 thousand transplants have been performed worldwide. Of these, about seven hundred were in Brazil. However, survival of the transplant is less than desired, with a high mortality rate related to primary graft dysfunction, infection, and chronic graft dysfunction, particularly in the form of bronchiolitis obliterans syndrome. New technologies have been developed to improve the various stages of lung transplant. To increase the supply of lungs, ex vivo lung reconditioning has been used in some countries, including Brazil. For advanced life support in the perioperative period, extracorporeal membrane oxygenation and hemodynamic support equipment have been used as a bridge to transplant in critically ill patients on the waiting list, and to keep patients alive until resolution of the primary dysfunction after graft transplant. There are patients requiring lung transplant in Brazil who do not even come to the point of being referred to a transplant center because there are only seven such centers active in the country. It is urgent to create new centers capable of performing lung transplantation to provide patients with some advanced forms of lung disease a chance to live longer and with better quality of life.
机译：摘要肺移植是一种全球公认的治疗某些晚期肺部疾病的方法，可使受体更长的生存期和更好的生活质量。自1983年成功进行第一例移植手术以来，全世界已进行了超过4万例移植手术。其中，约有700个在巴西。但是，移植物的存活率低于期望值，死亡率高，与原发性移植物功能障碍，感染和慢性移植物功能障碍有关，尤其是闭塞性细支气管炎综合征形式。已经开发出新技术来改善肺移植的各个阶段。为了增加肺部供应，在包括巴西在内的一些国家已经使用了离体肺修复。为了在围手术期提供更高的生命支持，体外膜氧合和血流动力学支持设备已被用作在等待名单上危重患者进行移植的桥梁，并保持患者的生命直至移植后原发功能障碍得以解决。在巴西，有一些需要肺移植的患者甚至没有被转介到移植中心，因为该国只有七个这样的中心在活动。迫切需要建立一个能够进行肺移植的新中心，为患有某些晚期肺病的患者提供更长寿和更高生活质量的机会。

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