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首页> 外文期刊>eLife journal >E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors’ activity in an E-box-dependent manner
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E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors’ activity in an E-box-dependent manner

机译：E蛋白通过依赖E-box的方式调节前神经bHLH转录因子的活性来增强神经发生

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The brain and spinal cord are made up of a range of cell types that carry out different roles within the central nervous system. Each type of neuron is uniquely specialized to do its job. Neurons are produced early during development, when they differentiate from a group of cells called neural progenitor cells. Within these groups, molecules called proneural proteins control which types of neurons will develop from the neural progenitor cells, and how many of them. Proneural proteins work by binding to specific patterns in the DNA, called E-boxes, with the help of E proteins. E proteins are typically understood to be passive partners, working with each different proneural protein indiscriminately. However, Le Dréau, Escalona et al. discovered that E proteins in fact have a much more active role to play. Using chick embryos, it was found that E proteins influence the way different proneural proteins bind to DNA. The E proteins have preferences for certain E-boxes in the DNA, just like proneural proteins do. The E proteins enhanced the activity of the proneural proteins that share their E-box preference, and reined in the activity of proneural proteins that prefer other E-boxes. As a result, the E proteins controlled the ability of these proteins to instruct neural progenitor cells to produce specific, specialized neurons, and thus ensured that the distinct types of neurons were produced in appropriate amounts. These findings will help shed light on the roles E proteins play in the development of the central nervous system, and the processes that control growth and lead to cell diversity. The results may also have applications in the field of regenerative medicine, as proneural proteins play an important role in cell reprogramming.
机译：大脑和脊髓由一系列在中枢神经系统中发挥不同作用的细胞组成。每种类型的神经元都有其独特的专业能力来完成其工作。当神经元与一组称为神经祖细胞的细胞分化时，它们会在发育的早期产生。在这些组中，称为前神经蛋白的分子控制着从神经祖细胞中发育出哪种类型的神经元，以及它们中有多少种。 proneural蛋白通过在E蛋白的帮助下结合到DNA中称为E-boxes的特定模式而起作用。 E蛋白通常被认为是被动配偶，不加区别地与每种不同的proneural蛋白一起工作。但是，LeDréau，Escalona等人。发现E蛋白实际上起着更为积极的作用。使用雏鸡胚胎，发现E蛋白影响不同的proneural蛋白与DNA结合的方式。 E蛋白对DNA中的某些E盒具有偏好，就像proneural蛋白一样。 E蛋白增强了共享其E-box偏爱的proneural蛋白的活性，并抑制了喜欢其他E-box的proneural蛋白的活性。结果，E蛋白控制了这些蛋白指示神经祖细胞产生特定的，专门的神经元的能力，从而确保以适当的数量产生不同类型的神经元。这些发现将有助于阐明E蛋白在中枢神经系统发育中的作用，以及控制生长和导致细胞多样性的过程。由于前体蛋白在细胞重编程中起重要作用，因此该结果也可能在再生医学领域中得到应用。

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