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Immunosenescence: participation of T lymphocytes and myeloid-derived suppressor cells in aging-related immune response changes

机译：免疫衰老：T淋巴细胞和髓样抑制细胞参与衰老相关的免疫反应变化

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摘要

Healthy aging is partly related to appropriate function of the immune system. As already reported, some changes in this system are observed, including reduced number and repertoire of T cells due to thymic involution, accumulation of memory T cells by chronic infections, homeostatic proliferation compensating for the number of na?ve T cells, decreased proliferation of T cells against a stimulus, telomere shortening, replicative senescence of the T cells, and inflammaging, besides the accumulation of myeloid-derived suppressor cells. The purpose of this article is to clarify each of these changes, aiming to minimize limitations of immunosenescence. If such associations can be established, these cells may be used as early and less invasive markers of aging-related diseases, as well as to indicate interventions, evaluate the efficacy of interventions and be a tool to achieve longevity with quality of life.
机译：健康的衰老部分与免疫系统的适当功能有关。正如已经报道的那样，该系统发生了一些变化，包括胸腺退化导致T细胞数量和种类减少，慢性感染引起的记忆T细胞积累，体内稳定的增殖补偿了天然T细胞的数量，T细胞增殖的减少。 T细胞除刺激髓样抑制细胞外，还具有刺激作用，端粒缩短，复制性衰老和发炎。本文的目的是阐明这些变化，以最大程度地减少免疫衰老的局限。如果可以建立这种联系，那么这些细胞就可以用作衰老相关疾病的早期和低侵入性标记，并可以指示干预措施，评估干预措施的有效性，并可以作为长寿和提高生活质量的工具。

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