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Evaluation and reconditioning of donor organs for transplantation through ex vivo lung perfusion

机译：通过离体肺灌注评估和修复供体移植器官

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Objective: To assess the feasibility and impact of ex vivo lung perfusion with hyperoncotic solution (Steen Solution ? ) in the utilization of these organs in Brazil. Methods: In this prospective study, we subjected five lungs considered to be high risk for transplantation to 4 hours of ex vivo lung perfusion, with evaluation of oxygenation capacity. High-risk donor lungs were defined by specific criteria, including inflammatory infiltrates, pulmonary edema and partial pressure of arterial oxygen less than 300mmHg (inspired oxygen fraction of 100%). Results: During reperfusion, the mean partial pressure of arterial oxygen (inspired oxygen fraction of 100%) of the lungs did not change significantly (p=0.315). In the first hour, the mean partial pressure of arterial oxygen was 302.7mmHg (±127.66mmHg); in the second hour, 214.2mmHg (±94.12mmHg); in the third hour, 214.4mmHg (±99.70mmHg); and in the fourth hour, 217.7mmHg (±73.93mmHg). Plasma levels of lactate and glucose remained stable during perfusion, with no statistical difference between the moments studied (p=0.216). Conclusion: Ex vivo lung perfusion was reproduced in our center and ensured the preservation of lungs during the study period, which was 4 hours. The technique did not provide enough improvement for indicating organs for transplantation; therefore, it did not impact on use of these organs.
机译：目的：评估在巴西使用高渗溶液（Steen Solution？）进行体外肺灌注对这些器官的利用的可行性和影响。方法：在这项前瞻性研究中，我们对5个被认为具有高移植风险的肺进行了4小时的离体肺灌注，并评估了其充氧能力。高风险供体肺由特定标准定义，包括炎性浸润，肺水肿和动脉血氧分压小于300mmHg（吸入氧分数为100％）。结果：在再灌注期间，肺的动脉血氧分压（吸入氧分数为100％）的平均分压没有显着变化（p = 0.315）。在第一个小时中，动脉血的平均分压为302.7mmHg（±127.66mmHg）;第二个小时为214.2mmHg（±94.12mmHg）;第三小时为214.4mmHg（±99.70mmHg）;第四小时为217.7mmHg（±73.93mmHg）。灌注期间乳酸和葡萄糖的血浆水平保持稳定，研究时刻之间无统计学差异（p = 0.216）。结论：在我们的中心复制了离体肺灌注，并确保了研究期间（4小时）的肺部保存。该技术没有为指示移植器官提供足够的改进。因此，它不会影响这些器官的使用。

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