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SPEM: a state-of-the-art instrument for high resolution molecular imaging of small animal organs

机译：SPEM：用于对小动物器官进行高分辨率分子成像的最先进仪器

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OBJECTIVE: To describe the Single Photon Emission Microscope (SPEM), a state-of-the-art instrument for small animal SPECT imaging, and characterize its performance presenting typical images of different animal organs. METHODS: SPEM consists of two independent imaging devices based on high resolution scintillators, high sensitivity and resolution Electron-Multiplying CCDs and multi-pinhole collimators. During image acquisition, the mouse is placed in a rotational vertical holder between the imaging devices. Subsequently, an appropriate software tool based on the Maximum Likelihood algorithm iteratively produces the volumetric image. Radiopharmaceuticals for imaging kidneys, heart, thyroid and brain were used. The mice were injected with 74 to 148 MBq/0,3mL and scanned for 40 to 80 minutes, 30 to 60 minutes afterwards. During this procedure, the animals remained under ketamine/xilazine anesthesia. RESULTS: SPEM images of different mouse organs are presented, attesting the imaging capabilities of the instrument. CONCLUSION: SPEM is an innovative technology for small animal SPECT imaging providing high resolution images with appropriate sensitivity for pre-clinical research. Its use with appropriate radiotracers will allow translational investigation of several animal models of human diseases, their pharmacological treatment and the development of potential new therapeutic agents.
机译：目的：描述单光子发射显微镜（SPEM），这是一种用于小动物SPECT成像的最新技术，并表征其表现不同动物器官的典型图像的性能。方法：SPEM由基于高分辨率闪烁器，高灵敏度和分辨率电子倍增CCD和多针孔准直器的两个独立的成像设备组成。在图像获取期间，将鼠标放置在成像设备之间的旋转垂直支架中。随后，基于最大似然算法的适当软件工具会迭代生成体积图像。使用了用于肾脏，心脏，甲状腺和大脑成像的放射性药物。给小鼠注射74至148MBq / 0.3mL，并在40至80分钟，30至60分钟后扫描。在此过程中，动物仍处于氯胺酮/甲苯噻嗪麻醉下。结果：给出了不同小鼠器官的SPEM图像，证明了该仪器的成像能力。结论：SPEM是一种用于小动物SPECT成像的创新技术，可为临床前研究提供具有适当灵敏度的高分辨率图像。将其与适当的放射性示踪剂一起使用，将可以对几种人类疾病的动物模型，它们的药理治疗和潜在的新治疗剂的开发进行翻译研究。

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