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Levodopa versus non-levodopa brain language fMRI in Parkinson's disease

机译：帕金森病左旋多巴与非左旋多巴脑语言功能磁共振成像

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OBJECTIVE: To identify the effect of levodopa in language areas in Parkinson's disease patients. METHODS: We evaluated 50 patients with mild to moderate Parkinson's disease, age and gender paired to 47 healthy volunteers. We selected two homogeneous groups of 18 patients taking levodopa and 7 no levodopa patients. The functional magnetic resonance imaging verbal fluency task, with low and high cognitive demands, was performed at a 3T magnetic resonance imaging equipment. Data was analyzed with XBAM software for group maps and ANOVA comparison. RESULTS: Patients without levodopa had more activation than the ones with levodopa in the medial frontal and in the left frontal and parieto-occipital areas. The striatal activation in patients taking levodopa had similar result of the activation detected in the healthy volunteer group. Parieto-occipital areas were less activated in the levodopa group than in the no levodopa one. CONCLUSION: Parkinson's disease patients without levodopa replacement, during a verbal fluency effort, had more diffuse and intense cerebral activation in left hemisphere, mainly in the frontal and parieto-occipital areas. The striatal activation in verbal fluency of patients with levodopa intake was more similar to the activation found in healthy volunteers. These initial evidences suggested a role of levodopa inhibiting activation in parieto-occipital compensating areas.
机译：目的：探讨左旋多巴对帕金森氏病患者语言区域的影响。方法：我们与47名健康志愿者配对，评估了50例轻度至中度帕金森病，年龄和性别患者。我们选择了18个服用左旋多巴的患者和7个未服用左旋多巴的患者，分为两组。在3T磁共振成像设备上执行具有低和高认知要求的功能性磁共振成像的口语流利性任务。使用XBAM软件分析数据以进行组图和ANOVA比较。结果：在左额额叶内侧和左额叶及顶枕区，左旋多巴的患者比左旋多巴的患者具有更多的激活作用。服用左旋多巴的患者的纹状体激活与健康志愿者组中检测到的激活结果相似。左旋多巴组的顶枕区激活程度比无左旋多巴组少。结论：未经左旋多巴替代的帕金森氏病患者，在口语流利期间，左半球（主要在额叶和顶枕区）的脑弥漫性和弥漫性较强。左旋多巴摄入患者的口语流利性纹状激活与健康志愿者中的激活更为相似。这些初步证据表明左旋多巴在顶枕补偿区域抑制激活。

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