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首页> 外文期刊>Emerging themes in epidemiology >Risk factors for tuberculosis in older children and adolescents: a matched case–control study in Recife, Brazil
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Risk factors for tuberculosis in older children and adolescents: a matched case–control study in Recife, Brazil

机译：大龄儿童和青少年结核病的危险因素：巴西累西腓的病例对照研究

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Background Tuberculosis is a major disease worldwide and most research focus on risk factors for adults, although there is a marked adolescent peak in incidence. The objective of this study was to identify risk factors for tuberculosis in children aged 7 to 19. Methods A case control study matched by age with 169 cases and 477 controls. The study population consisted of adolescents and older children from Recife, Brazil. Cases were individuals diagnosed with tuberculosis in the control programme and controls were selected in the neighborhood of cases. Conditional logistic regression was used to identify risk factors. Results Cigarette smoking increased by 50% the risk of tuberculosis but that this was not statistically significant (OR?=?1.6). Other risk factors were sleeping in the same house as a case of tuberculosis (OR?=?31.6), living in a house with no piped water (OR?=?7.7) (probably as a proxy for bad living conditions), illiteracy (OR?=?3.7) and male sex (OR?=?1.8). The increase in risk with living in houses with no piped water was much more marked in males. The proportion of cases of tuberculosis attributed to contact with someone with TB was 38% and to illiteracy, lack of piped water and smoking, 20%. Conclusion Household contact with tuberculosis, social factors and male sex play the biggest role in determining risk of TB disease among children and adolescents in the study. We recommend further research on the relationship of cigarette smoking on tuberculosis in adolescents, and on whether the sex differentials are more marked in bad living conditions. Separate studies should be conducted in older children and in adolescents.
机译：背景技术结核病是世界范围内的主要疾病，尽管青春期发病率出现明显峰值，但大多数研究都集中在成人的危险因素上。这项研究的目的是确定7至19岁儿童的结核病危险因素。方法病例对照研究按年龄进行匹配，共169例和477例对照。研究人群包括来自巴西累西腓的青少年和大孩子。病例是在对照程序中被诊断出患有肺结核的个体，并在病例附近选择了对照。条件对数回归用于确定危险因素。结果抽烟使患肺结核的风险增加了50％，但这没有统计学意义（OR≥1.6）。其他危险因素是与结核病在同一屋子里睡觉（OR？=？31.6），住在没有自来水的屋子里（OR？=？7.7）（可能是不良生活条件的代表），文盲（ OR？=？3.7）和男性（OR？=？1.8）。在没有自来水的房屋中生活的风险增加在男性中更为明显。与结核病患者接触的结核病例占38％，而由于文盲，缺乏自来水和吸烟而占20％。结论在本研究中，家庭接触结核病，社会因素和男性在确定儿童和青少年结核病风险中起最大作用。我们建议进一步研究吸烟与青少年结核病的关系，以及在不良生活条件下性别差异是否更为明显。应在较大的儿童和青少年中进行单独的研究。

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