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The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study

机译：儿童疫苗对鼻咽细菌携带的影响：一项纵向研究

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Background There is increasing evidence that childhood vaccines have effects that extend beyond their target disease. The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx. Methods A cohort of children from rural Gambia was recruited at birth and followed up for one year. Nasopharyngeal swabs were taken immediately after birth, every two weeks for the first six months and then every other month. The presence of bacteria in the nasopharynx (Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus) was compared before and after the administration of DTP-Hib-HepB and measles-yellow fever vaccines. Results A total of 1,779 nasopharyngeal swabs were collected from 136 children for whom vaccination data were available. The prevalence of bacterial carriage was high: 82.2% S. pneumoniae, 30.6%, S.aureus, 27.8% H. influenzae. Carriage of H. influenzae (OR?=?0.36; 95% CI: 0.13, 0.99) and S. pneumoniae (OR?=?0.25; 95% CI: 0.07, 0.90) were significantly reduced after measles-yellow fever vaccination; while DTP-Hib-HepB had no effect on bacterial carriage. Conclusions Nasopharyngeal bacterial carriage is unaffected by DTP-Hib-HepB vaccination and reduced after measles-yellow fever vaccination.
机译：背景技术越来越多的证据表明，儿童疫苗的作用已超出其目标疾病的范围。这项研究的目的是评估常规的儿童疫苗对鼻咽细菌携带的影响。方法招募了冈比亚农村地区的一组儿童，并对其进行了为期一年的随访。鼻咽拭子在出生后立即服用，头六个月每两周一次，然后每两个月一次。在施用DTP-Hib-HepB和麻疹-黄热疫苗之前和之后，比较了鼻咽中的细菌（流感嗜血杆菌，肺炎链球菌，金黄色葡萄球菌）的存在。结果从136名获得疫苗接种数据的儿童中共收集了1779支鼻咽拭子。细菌携带率很高：肺炎链球菌82.2％，金黄色葡萄球菌30.6％，流感嗜血杆菌27.8％。麻疹-黄热病疫苗接种后，流感嗜血杆菌（ORα=？0.36; 95％CI：0.13，0.99）和肺炎链球菌（ORα=？0.25; 95％CI：0.07,0.90）的携带率明显降低; DTP-Hib-HepB对细菌携带没有影响。结论鼻咽细菌运输不受DTP-Hib-HepB疫苗接种的影响，麻疹-黄热病疫苗接种后鼻咽细菌的运输减少。

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