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首页> 外文期刊>Einstein (So Paulo) >Liver markers, prevalence of the metabolic syndrome abnormalities and effect of Roux-en-Y gastric bypass in morbidly obese subjects
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Liver markers, prevalence of the metabolic syndrome abnormalities and effect of Roux-en-Y gastric bypass in morbidly obese subjects

机译：病态肥胖受试者的肝脏标志物，代谢综合征异常的发生率和Roux-en-Y胃搭桥术的影响

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ABSTRACTObjectives:To evaluate the relations between liver markers (GGT, ALT and AST) and the metabolic syndrome (and its components) in morbidly obese subjects, and to determine the response of these metabolic factors and hepatic enzymes after weight loss induced by Roux-en-Y gastric bypass.Methods:This study was carried out at a university hospital, in Santo André (SP), Brazil. We evaluated 140 morbidly obese subjects aged from 18 to 60 years submitted to a Roux-en-Y gastric bypass, who were followed for a mean period of 8 months. Patients with a history of heavy drinking, type 1 diabetes, and/or liver disease were excluded.Results:Liver markers, most notably GGT, were strongly associated with metabolic abnormalities, mainly hyperglycemia. The prevalence of type 2 diabetes significantly increased with increasing levels of GGT (highest versus lowest quartile GGT: odds ratio 3.89 [95%CI: 1.07-14.17]). Liver markers significantly decreased 8 months after the Roux-en-Y gastric bypass and the reduction of GGT levels were associated with the reduction of glucose levels (Pearson r = 0.286; p = 0.001).Conclusions:Elevated levels of liver markers, principally GGT, in morbidly obese subjects are associated with metabolic abnormalities. In addition to the well-known benefits of bariatric surgery, Roux-en-Y gastric bypass, reduced the levels of liver markers to the normal range.
机译：目的：评估病态肥胖受试者肝脏标志物（GGT，ALT和AST）与代谢综合征（及其成分）之间的关系，并确定Roux-en引起的减肥后这些代谢因子和肝酶的反应方法：这项研究是在巴西圣安德烈（SP）的一家大学医院进行的。我们评估了140名年龄在18至60岁之间的病态肥胖受试者，他们接受了Roux-en-Y胃搭桥术，平均随访8个月。结果：肝脏标志物，最明显的是GGT，与代谢异常，主要是高血糖，密切相关。随着GGT水平的升高，2型糖尿病的患病率显着增加（最高四分位数与最低四分位数GGT：比值比为3.89 [95％CI：1.07-14.17]）。 Roux-en-Y胃搭桥术后8个月肝标志物显着下降，GGT降低与葡萄糖水平降低相关（Pearson r = 0.286; p = 0.001）。结论：肝标志物水平升高，主要是GGT ，在病态肥胖的受试者中与代谢异常有关。除减肥手术的众所周知的好处外，Roux-en-Y胃搭桥术将肝脏标志物的水平降低至正常范围。

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