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首页> 外文期刊>Electronic Physician >Efficacy of Platelet-Rich Plasma versus Hyaluronic Acid for treatment of Knee Osteoarthritis: A systematic review and meta-analysis
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Efficacy of Platelet-Rich Plasma versus Hyaluronic Acid for treatment of Knee Osteoarthritis: A systematic review and meta-analysis

机译：富含血小板血浆与透明质酸治疗膝骨关节炎的疗效：系统评价和荟萃分析

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Introduction Knee osteoarthritis is a very common chronic degenerative disease that could impose significant costs to the health system. Although osteoarthritis can affect all joints, knee osteoarthritis is the most common type among adolescents. Non-surgical treatments include corticosteroids injection, hyaluronic acid, and platelet-rich plasma. The aim of this study was to investigate the efficiency of platelet-rich plasma versus hyaluronic acid for the treatment of knee osteoarthritis. Methods Pubmed, Cochran library, Scopus and Ovid databases were investigated to identify related studies from 2000 through August 2015. To study the efficiency, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) outcome using the Standard Mean Difference (SMD) index was calculated using a random model and a confidence interval of 95%. In addition, sensitivity and cumulative analysis were conducted. The data were analyzed using RevMan 5.3.5 and Stata 12 software. Results Seven studies with 722 subjects (364 participants in PRP and 358 participants in the HA group) were analyzed. The WOMAC PRP compared to HA, SMD = ?0.75 (95% CI: ?1.33 to ?0.18, I2 = 92.6%) in treatment of knee osteoarthritis was statistically significant and PRP was more effective. Conclusion The results of this meta-analysis two years after PRP injection showed the efficacy of PRP versus HA. However, further studies are required to determine the longer-term effects.
机译：简介膝骨关节炎是一种非常常见的慢性退行性疾病，可能会给卫生系统带来巨大的成本。尽管骨关节炎会影响所有关节，但膝盖骨关节炎是青少年中最常见的类型。非手术治疗包括糖皮质激素注射，透明质酸和富含血小板的血浆。这项研究的目的是研究富含血小板的血浆与透明质酸治疗膝盖骨关节炎的效率。方法调查Pubmed，Cochran图书馆，Scopus和Ovid数据库，以鉴定2000年至2015年8月之间的相关研究。为研究效率，使用标准均数差（SMD）指数计算西安大略省和麦克马斯特大学骨关节炎指数（WOMAC）的结果，随机模型和95％的置信区间。另外，进行了敏感性和累积分析。使用RevMan 5.3.5和Stata 12软件分析数据。结果分析了722名受试者的7项研究（PRP 364名受试者和HA组358名受试者）。 WOMAC PRP与HA相比，SMD = 0.75（95％CI：1.31.33至0.10.18，I2 = 92.6％）在膝骨关节炎治疗中具有统计学意义，PRP更有效。结论注射PRP两年后的荟萃分析结果显示PRP相对于HA的疗效。但是，需要进一步的研究来确定长期影响。

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