• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Emerging themes in epidemiology >Assessing observational studies of medical treatments
【24h】

Assessing observational studies of medical treatments

机译：评估药物治疗的观察性研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Previous studies have assessed the validity of the observational study design by comparing results of studies using this design to results from randomized controlled trials. The present study examined design features of observational studies that could have influenced these comparisons. Methods To find at least 4 observational studies that evaluated the same treatment, we reviewed meta-analyses comparing observational studies and randomized controlled trials for the assessment of medical treatments. Details critical for interpretation of these studies were abstracted and analyzed qualitatively. Results Individual articles reviewed included 61 observational studies that assessed 10 treatment comparisons evaluated in two studies comparing randomized controlled trials and observational studies. The majority of studies did not report the following information: details of primary and ancillary treatments, outcome definitions, length of follow-up, inclusion/exclusion criteria, patient characteristics relevant to prognosis or treatment response, or assessment of possible confounding. When information was reported, variations in treatment specifics, outcome definition or confounding were identified as possible causes of differences between observational studies and randomized controlled trials, and of heterogeneity in observational studies. Conclusion Reporting of observational studies of medical treatments was often inadequate to compare study designs or allow other meaningful interpretation of results. All observational studies should report details of treatment, outcome assessment, patient characteristics, and confounding assessment.
机译：背景技术先前的研究通过将使用该设计的研究结果与随机对照试验的结果进行比较，评估了观察性研究设计的有效性。本研究检查了可能影响这些比较的观察性研究的设计特征。方法为了找到至少4项评价相同治疗的观察性研究，我们回顾了比较观察性研究和随机对照试验以评估药物治疗的荟萃分析。对解释这些研究的关键细节进行了抽象和定性分析。结果评价的个别文章包括61项观察性研究，评估了10项治疗比较，两项比较随机对照试验和观察性研究的评价。大多数研究未报告以下信息：主要和辅助治疗的详细信息，结局定义，随访时间，纳入/排除标准，与预后或治疗反应相关的患者特征或可能混淆的评估。当报告信息时，治疗细节，结果定义或混淆的差异被确定为观察性研究与随机对照试验之间差异以及观察性研究异质性的可能原因。结论对药物治疗的观察性研究的报告通常不足以比较研究设计或对结果进行其他有意义的解释。所有观察性研究均应报告治疗细节，结果评估，患者特征和混杂评估。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号