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首页> 外文期刊>Emerging themes in epidemiology >Identifying related cancer types based on their incidence among people with multiple cancers
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Identifying related cancer types based on their incidence among people with multiple cancers

机译：根据多种癌症患者之间的发病率来确定相关的癌症类型

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Background There are several reasons that someone might be diagnosed with more than one primary cancer. The aim of this analysis was to determine combinations of cancer types that occur more often than expected. The expected values in previous analyses are based on age-and-gender-adjusted risks in the population. However, if cancer in people with multiple primaries is somehow different than cancer in people with a single primary, then the expected numbers should not be based on all diagnoses in the population. Methods In people with two or more cancer types, the probability that a specific type is diagnosed was determined as the number of diagnoses for that cancer type divided by the total number of cancer diagnoses. If two types of cancer occur independently of one another, then the probability that someone will develop both cancers by chance is the product of the individual probabilities for each type. The expected number of people with both cancers is the number of people at risk multiplied by the separate probabilities for each cancer. We performed the analysis on records of cancer diagnoses in British Columbia, Canada between 1970 and 2004. Results There were 28,159 people with records of multiple primary cancers between 1970 and 2004, including 1,492 people with between three and seven diagnoses. Among both men and women, the combinations of esophageal cancer with melanoma, and kidney cancer with oral cancer, are observed more than twice as often as expected. Conclusion Our analysis suggests there are several pairs of primary cancers that might be related by a shared etiological factor. We think that our method is more appropriate than others when multiple diagnoses of primary cancer are unlikely to be the result of therapeutic or diagnostic procedures.
机译：背景技术有人被诊断出患有多种原发癌的原因有很多。该分析的目的是确定发生频率超出预期的癌症类型的组合。先前分析中的期望值是基于人口中经过年龄和性别调整的风险。但是，如果具有多个原发性人群的癌症与具有单一原发性人群的癌症有所不同，则预期的数字不应基于人群中的所有诊断。方法在患有两种或多种癌症类型的人中，将特定类型的诊断概率确定为该癌症类型的诊断次数除以癌症诊断总数。如果两种类型的癌症彼此独立发生，那么某人偶然患上两种癌症的概率就是每种类型的个体概率的乘积。患有两种癌症的预期人数是每种癌症的风险人数乘以单独的概率。我们对1970年至2004年之间在加拿大不列颠哥伦比亚省的癌症诊断记录进行了分析。结果1970年至2004年之间，共有28,159人患有多种原发性癌症记录，其中1,492人具有3至7次诊断。在男性和女性中，食管癌合并黑色素瘤和肾癌合并口腔癌的发病率是预期的两倍以上。结论我们的分析表明，有几对原发癌可能与病因共享有关。当原发癌的多种诊断不太可能是治疗或诊断程序的结果时，我们认为我们的方法比其他方法更合适。

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