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首页> 外文期刊>Endocrine journal >LHRH Effects on Hippocampal Neurons Are Modulated by Estrogen in Rats
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LHRH Effects on Hippocampal Neurons Are Modulated by Estrogen in Rats

机译：LHRH对雌性大鼠海马神经元的调节作用

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References(40) Cited-By(3) The effect of luteinizing hormone releasing hormone (LHRH) on the neuronal activity of CA1 and CA3 regions of the hippocampus was studied by means of extracellular recordings in the castrated male, intact male, castrated female, and castrated female injected s.c. with 20μg estradiol benzoate (EB) for 3 days. The basal firing rate of the CA3 neurons of castrated EB-treated female rats was significantly lower than that of the neurons in castrated EB-untreated female rats as well as male rats, either intact or castrated, whereas that of the CA1 neurons was not significantly different from castrated EB-untreated female rats. Iontophoretically applied LHRH predominantly resulted in facilitation of the neuronal firing in most of the animal groups. In the CA3 region of castrated EB-treated female rats, however, inhibition occurred in a large percentage of neurons, and the ratio of facilitation, inhibition and no response was significantly different from that in castrated EB-untreated female rats. In the CA1 region of castrated EB-treated female rats, the predominant effect of LHRH was facilitation and the ratio of facilitation, inhibition and no response was not significantly different from that in castrated EB-untreated female rats. These results suggest that LHRH is involved in increasing the neuronal activity of the CA3 region in the hippocampus, and estrogen reduces this LHRH action.
机译：参考文献（40）Cited-By（3）通过of割的雄性，完整的雄性，cast割的雌性，雌性和雌性，研究了黄体生成激素释放激素（LHRH）对海马CA1和CA3区神经元活性的影响。和cast割的女性注射sc用20μg苯甲酸雌二醇（EB）持续3天。去势EB处理的雌性大鼠的CA3神经元的基础放电率显着低于未去势EB处理的雌性大鼠和雄性大鼠的神经元，无论是完整的还是去势的，而CA1神经元的基础放电均不明显。与cast割的未经EB治疗的雌性大鼠不同。离子电渗疗法应用LHRH主要导致大多数动物组神经元放电的促进。然而，在去势的EB处理的雌性大鼠的CA3区，抑制发生在很大比例的神经元中，与未去势的EB处理的雌性大鼠相比，促进，抑制和无反应的比率显着不同。在cast割的EB处理的雌性大鼠的CA1区，LHRH的主要作用是促进作用，与未cast割的EB处理的雌性大鼠相比，促进，抑制和无反应的比例无显着差异。这些结果表明，LHRH参与增加海马CA3区的神经元活性，而雌激素则降低了LHRH的作用。

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