...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Endocrine journal >Pathophysiological Significance of Plasma Total Renin and Prorenin in Patients with Diabetes Mellitus
【24h】

Pathophysiological Significance of Plasma Total Renin and Prorenin in Patients with Diabetes Mellitus

机译：糖尿病患者血浆总肾素和肾素原的病理生理意义

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

References(28) Cited-By(4) To seek the pathophysiologic significance of measuring the concentration of total renin instead of prorenin, we determined the plasma total renin concentration by immunoradiometric assay and correlated the results with various clinical features and laboratory parameters of diabetic complication in 108 patients with diabetes mellitus. The plasma prorenin concentration was estimated as the difference between the total and active renin concentrations. The plasma total renin and prorenin concentrations were high in patients with diabetes mellitus, in contrast to the active renin concentration which was slightly decreased. In addition, the plasma total renin and prorenin concentrations were higher in patients with diabetic complications than in patients without any complication. Multiple regression analysis showed that the presence of orthostatic hypotension, diabetic retinopathy, and proteinuria is significantly associated with the increased plasma total renin and prorenin concentrations. In addition, there was a significant positive correlation between the total renin and prorenin concentrations. These results suggest that both the plasma total renin concentration and the prorenin concentration are closely related to diabetic complications. Determination of the plasma total renin concentration by immunoradiometric assay as a substitute for prorenin could be a powerful tool in elucidating the mechanism for the increased plasma prorenin in diabetes mellitus.
机译：参考文献（28）（4）为了探讨测量总肾素浓度而不是原肾素的病理生理学意义，我们通过免疫放射测定法测定了血浆总肾素浓度，并将结果与​​糖尿病并发症的各种临床特征和实验室参数相关联在108名糖尿病患者中血浆中肾素浓度估计为总肾素浓度与活性肾素浓度之差。糖尿病患者血浆总肾素和原肾素浓度较高，而活性肾素浓度略有下降。此外，糖尿病合并症患者的血浆总肾素和肾素原浓度高于无并发症的患者。多元回归分析表明，体位性低血压，糖尿病性视网膜病变和蛋白尿的存在与血浆总肾素和肾素原浓度的升高显着相关。此外，总肾素和原肾素浓度之间存在显着的正相关。这些结果表明，血浆总肾素浓度和肾素原浓度均与糖尿病并发症密切相关。通过免疫放射测定法测定血浆总肾素浓度来替代肾上腺素，可能是阐明糖尿病中血浆肾素增加的机制的有力工具。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号