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首页> 外文期刊>Endocrine journal >Thyroid cancer in children: a 20-year study at a Romanian oncology institute
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Thyroid cancer in children: a 20-year study at a Romanian oncology institute

机译：儿童甲状腺癌：在罗马尼亚肿瘤学研究所进行的20年研究

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References(38) Cited-By(2) Thyroid carcinoma (TC) has an increasing incidence in the last decade and continues to represent the most frequent form of endocrine tumor. The aim of the study was to analyze the pediatric files of TC from the registry of “Prof. Dr. Ion Chiricuta” Institute of Oncology Cluj-Napoca, Romania (IOCN) and to provide the data related to the impact of nuclear fallout of Chernobyl on this pathology. We studied 72 children with TC treated between 1991 and 2010. The mean age was 15.3 years; the ratio female/male was 6.2:1. Twenty-nine children (40.2%) revealed metastasis in regional lymph nodes or lungs at the initial diagnostic. There were 63 differentiated thyroid carcinoma (DTC), 6 cases with medullary cancer (MC), 1 case with anaplastic carcinoma (AC), and 2 mixed cases. All patients underwent total thyroidectomy and the radioiodine was administered in 64 cases (activities between 1.1 - 28.1 GBq I-131). Fifty-two children (80.5%) are free of disease, 8 are in partial remission and 4 children are in evolution of the disease at minimum 12 months of follow-up. The incidence of TC was significantly increased 10 years after the accident. In the years after, the increasing trendline was stopped and at 25 years, the number of cases is stationary. The diagnosis of pediatric TC is made frequently in metastatic disease and the therapies must be conducted for many years till complete remission. A more clear strategy adapted to children is needed in the future.
机译：参考文献（38）被引用的By（2）甲状腺癌（TC）在最近十年中发病率不断上升，并且继续代表着最常见的内分泌肿瘤形式。该研究的目的是从“教授”的注册表中分析TC的儿科档案。 Ion Chiricuta博士”，罗马尼亚克卢日-纳波卡市肿瘤研究所（IOCN），并提供与切尔诺贝利核沉降对这种病理的影响有关的数据。我们研究了1991年至2010年间接受治疗的72例TC儿童。平均年龄为15.3岁。男女比例为6.2：1。初诊时有29名儿童（40.2％）表现出在局部淋巴结或肺部转移。分化型甲状腺癌（DTC）63例，髓样癌（MC）6例，间变性癌（AC）1例，混合型2例。所有患者均进行了全甲状腺切除术，并在64例患者中进行了放射性碘治疗（活动度在1.1-28.1 GBq I-131之间）。在至少12个月的随访中，有52名儿童（80.5％）没有疾病，有8名儿童部分缓解，有4名儿童正在患病。事故发生10年后，TC的发生率显着增加。在随后的几年中，上升趋势线停止了，并且在25年后，病例数保持稳定。小儿TC的诊断经常在转移性疾病中进行，并且治疗必须进行多年直至完全缓解。未来需要更清晰的策略来适应儿童。

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