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首页> 外文期刊>Endoscopy International Open >Frequency of coexistent carcinoma in sessile serrated adenoma/polyps and traditional serrated adenomas removed by endoscopic resection
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Frequency of coexistent carcinoma in sessile serrated adenoma/polyps and traditional serrated adenomas removed by endoscopic resection

机译：内镜下切除无固定型锯齿状腺瘤/息肉和传统锯齿状腺瘤并存癌的频率

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Background and study aims: Sessile serrated adenoma/polyps (SSA/Ps) have a different potential than traditional adenomatous polyps for developing into malignant colorectal cancer. However, little is known about the coexistent cancer rate. Here, we evaluate the frequency of carcinoma in serrated polyps removed by endoscopic resection (ER). Patients and methods: This was a retrospective single-center cohort study of consecutive patients with colorectal polyps who underwent ER from March 2003 to October 2014.?We determined the frequency of serrated polyps among all resected colorectal polyps and analyzed the clinicopathological findings as well as the frequency and characteristics of coexistent carcinoma in the serrated polyps resected by ER based on pathology reports. Results: A total of 21,048 polyps from 15,326 patients were identified, including 15,984 traditional adenomatous polyps (75.9?%), 621 SSA/Ps (3.0?%), 136 traditional serrated adenomas (TSAs) (0.6?%), 1,121 hyperplastic polyps (5.3?%), and 3,186 polyps of other types (15.1?%). The clinical and endoscopic findings of SSA/Ps revealed a male predominance (68.6?%), with 61.7?% of the polyps located in the proximal colon. Males accounted for 77.2?% of all patients with TSAs, and 77.2?% of these polyps were located in the distal colon. The mean sizes of the SSA/Ps and TSAs were 8.8 and 10.7?mm, respectively. Among the SSA/Ps, 8 (1.3?%) cases had coexistent carcinoma, and 1 (0.7?%) patient with TSA showed coexistent carcinoma. In the patients with SSA/Ps, female sex and a tumor size ≥?10?mm were predictive factors for coexistent carcinoma. Conclusions: The frequency of SSA/Ps with carcinoma was lower than that for traditional adenoma. Female sex and tumor size ≥?10?mm were significant predictive factors for coexistent carcinoma.
机译：背景和研究目标：无齿锯齿状腺瘤/息肉（SSA / Ps）与传统腺瘤性息肉发展为恶性大肠癌的潜力不同。但是，关于并存的癌症发生率知之甚少。在这里，我们评估通过内窥镜切除术（ER）去除的锯齿状息肉中的癌变频率。患者和方法：这是一项回顾性单中心队列研究，研究对象是2003年3月至2014年10月接受ER治疗的连续大肠息肉患者。我们确定了所有切除的大肠息肉中锯齿状息肉的发生率，并分析了其临床病理结果以及根据病理报告，ER切除的锯齿状息肉中共存癌的频率和特征。结果：共鉴定出15326名患者的21048息肉，包括15984例传统腺瘤性息肉（75.9％），621例SSA / Ps（3.0 %%），136例传统锯齿状腺瘤（TSA）（0.6 %%），1121例增生性息肉（5.3％），以及其他类型的3,186例息肉（15.1％）。 SSA / Ps的临床和内窥镜检查结果显示，男性占多数（68.6％），息肉中有61.7％位于近端结肠。男性占所有TSA患者的77.2％，这些息肉位于远端结肠，占77.2％。 SSA / Ps和TSA的平均大小分别为8.8和10.7？mm。在SSA / Ps中，8例（1.3％）的癌症并存，1例（0.7 %%）的TSA癌并存。在SSA / Ps患者中，女性和肿瘤大小≥？10？mm是共存癌的预测因素。结论：SSA / Ps伴癌的发生率低于传统腺瘤。女性和肿瘤大小≥？10？mm是并存癌的重要预测因素。

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