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首页> 外文期刊>Endocrine journal >Association of Antipituitary Antibody and Type 2 Iodothyronine Deiodinase Antibody in Patients with Autoimmune Thyroid Disease
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Association of Antipituitary Antibody and Type 2 Iodothyronine Deiodinase Antibody in Patients with Autoimmune Thyroid Disease

机译：自身免疫性甲状腺疾病患者的抗垂体抗体和2型碘甲状腺素脱碘酶抗体的关联

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References(29) Cited-By(5) Antipituitary antibody (APA) has been reported to be detected in patients with autoimmune thyroid disease. Type 2 iodothyronine deiodinase (D2) is expressed in both pituitary gland and thyroid gland. We studied the association of APA and D2 peptide antibody in patients with autoimmune thyroid disease. Rat pituitary gland homogenate and D2 peptide were used as antigens in the present study. APA and D2 peptide antibodies were measured by enzyme-linked immunosorbent assay (ELISA) in sera obtained from 42 patients with Hashimoto's disease, 26 patients with Graves' disease and 70 healthy control subjects. Moreover, D2 activity precipitation assay was performed in some patients with Hashimoto's disease. APA and D2 peptide antibody were elevated in patients with Hashimoto's disease and patients with Graves' disease, compared with control subjects. APA was positive in 32.4% (22/68), D2 peptide antibody was positive in 26.5% (18/68) of patients with autoimmune thyroid disease. APA was positive in 31.0% (13/42) of patients with Hashimoto's disease and 34.6% (9/26) of patients with Graves' disease. D2 peptide antibody was positive in 26.2% (11/42) of patients with Hashimoto's disease and 26.9% (7/26) of patients with Graves' disease. D2 peptide antibody was correlated with APA in patients with autoimmune thyroid disease. Moreover, precipitation of D2 activity was increased in some patients with Hashimoto's disease including a patient who also had idiopathic diabetes insipidus, and was correlated with D2 peptide antibody. These results suggest that D2 antibody may be associated with APA in patients with autoimmune thyroid disease.
机译：参考文献（29）被引用的By（5）抗垂体抗体（APA）在患有自身免疫性甲状腺疾病的患者中被检测到。 2型碘甲状腺素脱碘酶（D2）在垂体和甲状腺中都有表达。我们研究了自身免疫性甲状腺疾病患者中APA和D2肽抗体的关联。大鼠垂体匀浆和D2肽在本研究中用作抗原。通过酶联免疫吸附测定（ELISA）在42例桥本氏病患者，26例格雷夫斯氏病患者和70例健康对照者的血清中测量APA和D2肽抗体。此外，在某些桥本氏病患者中进行了D2活性沉淀试验。与对照组相比，桥本病患者和格雷夫斯病患者的APA和D2肽抗体升高。自身免疫性甲状腺疾病患者中，APA阳性率为32.4％（22/68），D2肽抗体阳性率为26.5％（18/68）。桥本病患者的31.0％（13/42）和Graves病患者的34.6％（9/26）的APA阳性。 D2肽抗体在桥本病患者中占26.2％（11/42），在格雷夫斯病患者中为26.9％（7/26）。 D2肽抗体与自身免疫性甲状腺疾病患者的APA相关。此外，在一些患有桥本氏病的患者中，包括也患有特发性尿崩症的患者中，D2活性的沉淀增加，并且与D2肽抗体相关。这些结果表明，D2抗体可能与自身免疫性甲状腺疾病患者的APA相关。

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