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首页> 外文期刊>Endocrine journal >The relationship of epicardial adipose tissue thickness to clinical and biochemical features in women with polycystic ovary syndrome
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The relationship of epicardial adipose tissue thickness to clinical and biochemical features in women with polycystic ovary syndrome

机译：多囊卵巢综合征女性心外膜脂肪组织厚度与临床及生化特征的关系

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References(36) Cited-By(6) The amount of epicardial adipose tissue (EAT), a component of body visceral adiposity, has been linked to the presence and severity of cardiovascular disease through multiple mechanisms. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance and subclinical inflammation, which participate in the mechanism of atherosclerosis. We searched if the patients with PCOS have increased EAT thickness (EATT), along with its relation to the measures of adiposity and insulin sensitivity. A total of 41 subjects with PCOS and 46 age and body mass index (BMI) matched healthy controls were enrolled. EAT was measured by echocardiography above the free wall of the right ventricle. Insulin resistance was assessed by homeostasis model assessment of insulin resistance (HOMA-IR) formula, and plasma adiponectin level was measured by ELISA. Compared to healthy controls EATT and HOMA-IR score were significantly higher (p=0.0001 for both) while plasma adiponectin concentration was significantly lower (p=0.048) in women with PCOS. EATT correlated positively with total cholesterol, triglyceride, luteinizing hormone (LH) and negatively with sex hormon binding globuline (pp=0.924). Triglyceride level was the significant determinant of EATT in logistic regression analysis (p=0.035). Thickness of the EAT is increased in patients with PCOS in conjunction with hyperandrogenity. Prospective studies are required to identify the relation of EAT and cardiovascular risk in patients with PCOS.
机译：参考文献（36）（6）被引用的心外膜脂肪组织（EAT）的量是体内内脏脂肪的组成部分，它通过多种机制与心血管疾病的存在和严重程度相关。多囊卵巢综合征（PCOS）的特征是胰岛素抵抗和亚临床炎症，参与动脉粥样硬化的机制。我们研究了PCOS患者是否增加了EAT厚度（EATT），以及其与肥胖和胰岛素敏感性的相关性。共有41位PCOS受试者和46位年龄和体重指数（BMI）匹配的健康对照组参加。通过超声心动图测量右心室自由壁上方的EAT。通过胰岛素抵抗的稳态模型评估（HOMA-IR）公式评估胰岛素抵抗，并通过ELISA测量血浆脂联素水平。与健康对照组相比，患有PCOS的女性的EATT和HOMA-IR评分显着较高（两者均为p = 0.0001），而血浆脂联素浓度显着较低（p = 0.048）。 EATT与总胆固醇，甘油三酸酯，黄体生成激素（LH）正相关，与性激素结合球蛋白（pp = 0.924）负相关。甘油三酯水平是逻辑回归分析中EATT的重要决定因素（p = 0.035）。患有高雄激素症的PCOS患者的EAT厚度增加。需要进行前瞻性研究以确定PCOS患者EAT与心血管风险的关系。

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