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首页> 外文期刊>Endoscopy International Open >Diagnostic performance of endoscopic ultrasound-guided fine-needle aspiration for cystic and non-cystic pancreatic neuroendocrine tumors
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Diagnostic performance of endoscopic ultrasound-guided fine-needle aspiration for cystic and non-cystic pancreatic neuroendocrine tumors

机译：内镜超声引导下细针穿刺对囊性和非囊性胰腺神经内分泌肿瘤的诊断性能

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Background and study aims?Pancreatic neuroendocrine tumors (P-NENs) are rare tumors with malignant potential. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has been shown to be superior to other imaging methods in preoperative localization and diagnosis of P-NENs. The objective of this study was to describe the EUS features of non-metastatic cystic and non-cystic P-NENs seen at a referral center and to evaluate the performance of EUS-FNA in diagnosis of P-NENs. Patients and methods?All patients with histologically confirmed, non-metastatic P-NENs, which underwent EUS-FNA prior to surgical resection at the Moffitt Cancer Center between Jan 2005 and Dec 2012 were included. Clinical, endoscopic and pathologic information was abstracted from electronic medical records. Results?Thirty-nine patients, all with non-functional P-NENs, were included in this study. Thirteen tumors were cystic and 26 were solid. Among the cystic tumors, 50?% were partly cystic and partly solid, and 50?% were fully cystic. The cystic tumors were more commonly seen at the body/tail, and the solid tumors were more uniformly distributed. Fluid could be aspirated from 50?% of the cystic tumors, all with a carcinoembryonic antigen level ?192?ng/mL. With surgical pathology as the gold standard, overall sensitivity of EUS-FNA in diagnosing cystic tumors was 62.5?%, and for solid tumors, 95?% (P??0.03). Conclusions?EUS-FNA is much more sensitive in diagnosing solid P-NENs than cystic PNETs. Our results indicate that EUS-FNA may have higher sensitivity for diagnosis of cystic P-NENs than the reported sensitivity of EUS-FNA for all pancreatic cystic tumors.
机译：背景与研究目的胰腺神经内分泌肿瘤（P-NENs）是具有恶性潜力的罕见肿瘤。内镜超声引导下细针穿刺抽吸术（EUS-FNA）在术前定位和诊断P-NENs方面优于其他成像方法。这项研究的目的是描述在转诊中心发现的非转移性囊性和非囊性P-NEN的EUS特征，并评估EUS-FNA在诊断P-NEN中的性能。患者和方法：包括2005年1月至2012年12月在Moffitt癌症中心进行手术切除并经EUS-FNA进行组织学证实的非转移性P-NENs的所有患者。从电子病历中提取临床，内窥镜和病理学信息。结果：本研究纳入了39例均伴有非功能性P-NEN的患者。 13例为囊性肿瘤，26例为实体瘤。在囊性肿瘤中，50％为部分囊性和部分实体，50​​％为完全囊性。囊性肿瘤更常见于身体/尾巴，实体瘤分布更均匀。可以从50％的囊性肿瘤中抽出积液，所有肿瘤的癌胚抗原水平<？192？ng / mL。以手术病理学为金标准，EUS-FNA在诊断囊性肿瘤中的总体敏感性为62.5％，对于实体瘤为95％（P 0.03）。结论：EUS-FNA在诊断固体P-NENs方面比囊性PNETs敏感得多。我们的结果表明，EUS-FNA对囊性P-NENs的诊断敏感性可能比报道的EUS-FNA对所有胰腺囊性肿瘤的敏感性更高。

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