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首页> 外文期刊>Endoscopy International Open >Clinicopathological features and endoscopic characteristics of inverted sessile serrated adenomas/polyps
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Clinicopathological features and endoscopic characteristics of inverted sessile serrated adenomas/polyps

机译：无柄锯齿状腺瘤/息肉的临床病理特征和内镜特征

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Background and study aims This study was designed to clarify clinicopathological, endoscopic, and genetic characteristics of inverted sessile serrated adenomas/polyps. Patients and methods In this retrospective study, we reviewed the pathology reports of patients treated in our hospital between January 2010 and June 2015 and identified sessile serrated adenomas/polyps that were diagnosed with endoscopic resected specimens. Clinicopathological, endoscopic, and genetic features were compared between the inverted and ordinary types. Results Among the 104 sessile serrated adenomas/polyps, 37 lesions were inverted (35.6?%). The inverted types had two patterns of invasion: expansive and infiltrating growth. Expansive growth was observed in 15 cases (40.5?%) and infiltrating in 22 (59.5?%). Regarding the clinicopathological findings and endoscopic characteristics of the inverted types, presence of adherent mucous, location in the right-side colon, an expanded type-II pit pattern, irregularly dilated vessels, and a depression were demonstrated in 89?% (33/37), 73?% (27/37), 54?% (20/37), 75?% (28/37), and 35 % (13/37), respectively. Contrastingly, these were demonstrated in 86?% (58/67), 84?% (56/67), 55?% (37/67), 58?% (39/67), and 0?% (0/67), respectively, in the ordinary type. In the univariate analysis, male sex and a depression in the adenoma/polyp were significantly associated with inverted types ( P ?0.001). BRAF mutation at codon 600 was found in six of seven ordinary types and in 11 of 11 of the inverted types. KRAS, NRAS, and PIK3CA mutations were not found in the ordinary and inverted types. Conclusion More than 30?% of sessile serrated adenomas/polyps were pathologically diagnosed as inverted, and approximately 40?% of them were of the expansive growth type and easily diagnosed with endoscopy. sup*/sup These authors contributed equally.
机译：背景和研究目的本研究旨在阐明无柄锯齿状腺瘤/息肉的临床病理，内镜和遗传特征。患者和方法在这项回顾性研究中，我们回顾了2010年1月至2015年6月间在我院接受治疗的患者的病理报告，并确定了诊断为内窥镜切除标本的无柄锯齿状腺瘤/息肉。比较倒置型和普通型的临床病理，内镜和遗传特征。结果在104例无柄锯齿状腺瘤/息肉中，有37处病变被倒置（占35.6％）。倒立型有两种入侵模式：扩张型和浸润型。 15例（40.5％）发生了广泛的增长，22例（59.5％）发生了浸润。关于倒置型的临床病理学发现和内窥镜特征，粘液的存在，右侧结肠的位置，II型凹坑扩大，血管不规则扩张和凹陷的发生率为89？％（33/37）。 ），73％（27/37），54％（20/37），75％（28/37）和35％（13/37）。相反，这些被证明为86％（58/67），84％（56/67），55％（37/67），58％（39/67）和0％（0/67） ）分别以普通类型显示。在单变量分析中，男性和腺瘤/息肉的凹陷与倒立型显着相关（P <0.001）。在7个普通类型中的6个和11个反向类型中的11个中发现了600位密码子的BRAF突变。在普通和反向类型中均未发现KRAS，NRAS和PIK3CA突变。结论在病理学上，无柄锯齿状腺瘤/息肉中有30％以上被诊断为倒置，其中约40％为扩张型且易于内镜检查。 * 这些作者做出了同样的贡献。

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