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首页> 外文期刊>Irish Veterinary Journal >Systemic fungal infection in a dog: a unique case in Ireland
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Systemic fungal infection in a dog: a unique case in Ireland

机译：狗的全身性真菌感染：爱尔兰的一个特例

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A three year old male entire Staffordshire bull terrier was referred to University College Dublin Veterinary Hospital, with a two week history of fever, inflammation of the right hock, lameness on the right hindlimb, peripheral lymphadenopathy and gastrointestinal signs (vomiting and diarrhoea). For the preceding three months the dog had been treated for atopic dermatitis with oral ciclosporin (5?mg/kg, PO, q 24?hours). Cytological analysis of the affected lymph nodes demonstrated fungal-like organisms predominantly contained within macrophages. Subsequent fungal culture and microscopic identification confirmed the presence of a Byssochlamys sp. This fungus is a saprophytic organism which has been associated with mycotoxin production. It has not previously been identified as a cause of systemic infection in animals or humans. Ciclosporin was discontinued, and a second generation triazole, voriconazole prescribed at a dose of 6?mg/kg for the first two doses, and continued at 3?mg/kg every 12?hours for six months. There was an excellent response. Follow-up examination five weeks after treatment was completed confirmed remission of the disease. The dog remains alive and well three years later. The present case represents an unusual fungal infection in a dog secondary to immunosuppressive therapy with ciclosporin. Such a possibility should be considered in animals presenting with signs consistent with systemic infection when receiving immunosuppressive medication.
机译：一名三岁的雄性整个斯塔福德郡斗牛犬被转诊至都柏林大学兽医学院，其有两周的发烧史，右侧飞节发炎，右侧后肢la行，周围淋巴结肿大和胃肠道症状（呕吐和腹泻）。在之前的三个月中，已用口服环孢素（5？mg / kg，PO，每24小时一次）治疗狗的特应性皮炎。受影响的淋巴结的细胞学分析表明，巨噬细胞内主要含有真菌样生物。随后的真菌培养和显微镜鉴定证实了Byssochlamys sp。的存在。这种真菌是腐生生物，与霉菌毒素的产生有关。以前尚未确定它是引起动物或人类全身感染的原因。停用环孢菌素，前两剂的第二代三唑伏立康唑的剂量为6？mg / kg，并每12小时以3？mg / kg的剂量持续6个月。响应很好。治疗结束五周后进行随访检查，确认该病已缓解。这只狗还活着，三年后还活着。本病例代表在用环孢菌素免疫抑制治疗继发的狗中的不寻常真菌感染。当接受免疫抑制药物时，表现出与全身感染一致的体征的动物应考虑这种可能性。

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