Concordant and discordant adrenocorticotropin (ACTH) responses induced by growth hormone-releasing peptide-2 (GHRP-2), corticotropin-releasing hormone (CRH) and insulin-induced hypoglycemia in patients with hypothalamopituitary disorders: evidence for direct ACTH releasing activity of GHRP-2

Akinori Tokitou; Akira Shimatsu; Chuwa Tei; Hideki Mori; Hiroshi Arimura; Michiyo Fukudome; Mitsuhiro Nakazaki; Takashi Kimura

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Concordant and discordant adrenocorticotropin (ACTH) responses induced by growth hormone-releasing peptide-2 (GHRP-2), corticotropin-releasing hormone (CRH) and insulin-induced hypoglycemia in patients with hypothalamopituitary disorders: evidence for direct ACTH releasing activity of GHRP-2

机译：下丘脑垂体疾病患者生长激素释放肽2（GHRP-2），促肾上腺皮质激素释放激素（CRH）和胰岛素引起的低血糖引起的肾上腺皮质激素（ACTH）一致和不一致的反应：GHRP-直接释放ACTH的证据2

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References(19) Cited-By(4) The insulin-induced hypoglycemia test (insulin tolerance test: ITT) and corticotropin-releasing hormone (CRH) test are used to examine the activities of the hypothalamo-pituitary-adrenal (HPA) axis. Growth hormone-releasing peptide-2 (GHRP-2), a potent GH secretagogue, also stimulates adrenocorticotropin (ACTH) secretion. To evaluate the role of GHRP-2 in assessing the HPA axis, we examined 6 patients with various hypothalamo-pituitary disorders, and measured ACTH and cortisol responses during provocative tests (ITT, CRH, and GHRP-2 test). None of the 6 patients showed any significant ACTH or cortisol responses to ITT, but significant ACTH release was observed during CRH and GHRP-2 tests. These findings suggest GHRP-2 may directly stimulate ACTH secretion in patients with hypothalamopituitary disorders.

机译：参考文献（19）引用（4）胰岛素诱导的低血糖测试（胰岛素耐受性测试：ITT）和促肾上腺皮质激素释放激素（CRH）测试用于检查下丘脑-垂体-肾上腺（HPA）轴的活动。生长激素释放肽2（GHRP-2），一种有效的GH促分泌素，也刺激肾上腺皮质激素（ACTH）分泌。为了评估GHRP-2在评估HPA轴中的作用，我们检查了6名患有各种下丘脑-垂体疾病的患者，并在刺激性测试（ITT，CRH和GHRP-2测试）中测量了ACTH和皮质醇的反应。 6例患者均未显示对ITT有任何显着的促肾上腺皮质激素或皮质醇反应，但在CRH和GHRP-2测试期间观察到显着的促肾上腺皮质激素释放。这些发现表明GHRP-2可能直接刺激下丘脑垂体疾病患者的ACTH分泌。

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《Endocrine journal》 |2010年第7期|共页
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Akinori Tokitou; Akira Shimatsu; Chuwa Tei; Hideki Mori; Hiroshi Arimura; Michiyo Fukudome; Mitsuhiro Nakazaki; Takashi Kimura;
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中图分类内分泌腺疾病及代谢病;
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1. Concordant and discordant adrenocorticotropin (ACTH) responses induced by growth hormone-releasing peptide-2 (GHRP-2), corticotropin-releasing hormone (CRH) and insulin-induced hypoglycemia in patients with hypothalamo-pituitary disorders: evidence for direct ACTH releasing activity of GHRP-2 [J] . Takashi Kimura, Akira Shimatsu, Hiroshi Arimura, Endocrine journal . 2010,第7期

机译：下丘脑-垂体疾病患者生长激素释放肽2（GHRP-2），促肾上腺皮质激素释放激素（CRH）和胰岛素引起的低血糖引起的肾上腺皮质激素（ACTH）一致和不一致的反应：促肾上腺皮质激素直接释放ACTH的证据GHRP-2
2. Growth hormone-releasing peptide-2 (GHRP-2) acts synergistically with growth hormone-releasing hormone (GHRH) to release growth hormone (GH) in swine [J] . Long Thang PHUNG, Nobuyoshi MATSUNAGA, Satoshi HIDAKA, 日本畜産学会報 . 2001,第4期

机译：生长激素释放肽2（GHRP-2）与生长激素释放激素（GHRH）协同作用以释放猪中的生长激素（GH）
3. Effects of Muscarinic and Adrenergic Blockade on Growth Hormone Secretion Induced by Growth Hormone-Releasing Peptide-2 (GHRP-2) in Ovariectomized Ewes [J] . HISASHI HIDARI, MAO LONG HE, MINORU HIROTA, Endocrine journal . 1997,第6期

机译：毒蕈碱和肾上腺素能阻断对去卵巢母羊生长激素释放肽-2（GHRP-2）诱导的生长激素分泌的影响。
4. Vasopressin stimulation of adrenocorticotropin hormone (ACTH) in humans. In vivo bioassay of corticotropin-releasing factor (CRF) which provides evidence for CRF mediation of the diurnal rhythm of ACTH. [O] . R A Salata, D B Jarrett, J G Verbalis, 1988

机译：加压素刺激人的肾上腺皮质激素（ACTH）。促肾上腺皮质激素释放因子（CRF）的体内生物测定为CRF介导ACTH的昼夜节律提供了证据。
5. Growth Hormone-Releasing Peptide-2 (GHRP-2) Acts Synergistically with Growth Hormone-Releasing Hormone (GHRH) to Release Growth Hormone (GH) in Swine [O] . Long Thang PHUNG, Nobuyoshi MATSUNAGA, Satoshi HIDAKA, 2001

机译：生长激素释放肽-2（GHRP-2）与生长激素释放激素（GHRH）协同作用，以在猪中释放生长激素（GH）

Concordant and discordant adrenocorticotropin (ACTH) responses induced by growth hormone-releasing peptide-2 (GHRP-2), corticotropin-releasing hormone (CRH) and insulin-induced hypoglycemia in patients with hypothalamopituitary disorders: evidence for direct ACTH releasing activity of GHRP-2

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