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首页> 外文期刊>Endocrine journal >Cardiac production of B-type natriuretic peptide is inversely related to the plasma level of free fatty acids in obese individuals - possible involvement of the insulin resistance -
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Cardiac production of B-type natriuretic peptide is inversely related to the plasma level of free fatty acids in obese individuals - possible involvement of the insulin resistance -

机译：B型利尿钠肽的心脏产生与肥胖个体的血浆游离脂肪酸水平呈负相关-可能与胰岛素抵抗有关-

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References(46) Cited-By(11) B-type natriuretic peptide (BNP) is produced by the heart and its plasma level is increased with the severity of left ventricular (LV) dysfunction/hypertrophy. The normal heart preferentially utilizes fatty acids as energy substrates. Plasma BNP levels are reported to be lower in obese individuals. We examined the relationship between BNP production and plasma free fatty acids (FFA), homeostasis model assessment of insulin resistance (HOMA-IR), and LV dysfunction/ hypertrophy. We examined the plasma BNP levels and FFA at the aortic root (AO) and coronary sinus (CS) as well as hemodynamic parameters in 62 patients (38 men and 24 women, 62.5±11.7 yrs) who underwent cardiac catheterization. Log BNP (AO) had a significant positive correlation with log BNP (CS-AO) (r=0.877, PPPPPPP=0.001). The multivariable regression analyses including log HOMA-IR, LVMI, and age as an independent variable revealed that HOMA-IR and LVMI were significant predictors of log BNP (CS-AO) or BNP production (P=0.001 and 0.004, respectively). We conclude that plasma BNP levels are determined primarily by cardiac production and that insulin resistance is a significant predictor of cardiac BNP production independent of LV hypertrophy in obese individuals.
机译：参考文献（46）被引出的By（11）B型利钠肽（BNP）由心脏产生，其血浆水平随左心室（LV）功能障碍/肥大的严重程度而增加。正常心脏优先利用脂肪酸作为能量底物。据报道，肥胖个体血浆BNP水平较低。我们检查了BNP产生与血浆游离脂肪酸（FFA），胰岛素抵抗稳态模型评估（HOMA-IR）和LV功能障碍/肥大之间的关系。我们检查了62例接受心脏导管检查的患者（38例男性和24例女性，62.5±11.7岁）的主动脉根（AO）和冠状窦（CS）血浆BNP水平和FFA以及血液动力学参数。 Log BNP（AO）与log BNP（CS-AO）呈显着正相关（r = 0.877，PPPPPPP = 0.001）。包括log HOMA-IR，LVMI和年龄作为自变量的多变量回归分析表明，HOMA-IR和LVMI是log BNP（CS-AO）或BNP产生的重要预测因子（分别为P = 0.001和0.004）。我们得出结论，血浆BNP水平主要由心脏产生决定，并且胰岛素抵抗是肥胖个体中独立于LV肥大的心脏BNP产生的重要预测因子。

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