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首页> 外文期刊>Endocrine journal >Resveratrol exerts anti-obesity effects in high-fat diet obese mice and displays differential dosage effects on cytotoxicity, differentiation, and lipolysis in 3T3-L1 cells
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Resveratrol exerts anti-obesity effects in high-fat diet obese mice and displays differential dosage effects on cytotoxicity, differentiation, and lipolysis in 3T3-L1 cells

机译：白藜芦醇在高脂饮食肥胖小鼠中具有抗肥胖作用，并且对3T3-L1细胞的细胞毒性，分化和脂解作用具有不同的剂量作用

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References(41) Cited-By(3) Studies on resveratrol in a wide range of concentrations on obese mice and adipose cells are necessary to comprehend its range of diverse and contradictory effects. In this study, we examined the anti-obesity effects of resveratrol on high-fat diet (HFD)-induced obese mice at dosages ranging from 1 to 30 mg/kg treatment for 10 wk. We also evaluated the effects of resveratrol on cytotoxicity, proliferation, adipogenic differentiation, and lipolysis of 3T3-L1 cells at concentrations ranging from 0.03 to 100 μM. In HFD obese mice, resveratrol treatment for 10 wk without decreased calories intake significantly attenuated HFD-induced weight gain in a dose-dependent manner. Resveratrol treatment also protected against HFD-induced lipid deposition in adipose tissues and liver. In cultured 3T3-L1 preadipocytes, high dosage (10 to 100 μM) resveratrol treatment produced cytotoxicity in both preadipocytes and mature adipocytes. In contrast, low concentration resveratrol treatment (1 to 10 μM) significantly inhibited the capacity of 3T3-L1 cells differentiated into mature adipocytes. Low dose resveratrol treatment also downregulated peroxisome proliferator-activated receptor gamma (PPARγ) and perilipin protein expressions in differentiated adipocytes. Additionally, tumor necrosis factor alpha (TNFα)-induced lipolysis was inhibited by low concentration resveratrol treatment in mature adipocytes. At concentrations of 10-100 μM, resveratrol exerted cytotoxicity. In contrast, at concentrations of 1-10 μM resveratrol inhibited adipogenic differentiation in preadipocytes and suppressed lipolysis in mature adipocytes. Our results suggest that resveratrol possessed anti-obesity effects by induction of cytotoxicity at high dosage and that it influences preadipocyte differentiation and mature adipocyte lipolysis at low concentration.
机译：参考文献（41）Cyted-By（3）研究肥胖小鼠和脂肪细胞中白藜芦醇的浓度范围很广，以了解其多样化和相互矛盾的作用。在这项研究中，我们研究了白藜芦醇对高脂饮食（HFD）诱导的肥胖小鼠的抗肥胖作用，剂量范围为1至30 mg / kg，治疗10周。我们还评估了白藜芦醇对浓度为0.03至100μM的3T3-L1细胞的细胞毒性，增殖，成脂分化和脂解的影响。在HFD肥胖小鼠中，白藜芦醇治疗10 wk且卡路里摄入量未减少，以剂量依赖性方式显着减弱了HFD诱导的体重增加。白藜芦醇治疗还可以防止HFD诱导的脂肪沉积在脂肪组织和肝脏中。在培养的3T3-L1前脂肪细胞中，高剂量（10至100μM）白藜芦醇处理对前脂肪细胞和成熟脂肪细胞均产生细胞毒性。相反，低浓度白藜芦醇处理（1至10μM）显着抑制了分化为成熟脂肪细胞的3T3-L1细胞的能力。低剂量白藜芦醇治疗还下调了分化脂肪细胞中的过氧化物酶体增殖物激活受体γ（PPARγ）和外周血脂蛋白的表达。此外，在成熟脂肪细胞中低浓度白藜芦醇治疗可抑制肿瘤坏死因子α（TNFα）诱导的脂解。在10-100μM的浓度下，白藜芦醇具有细胞毒性。相反，在1-10μM的浓度下，白藜芦醇抑制前脂肪细胞中的脂肪形成分化，并抑制成熟脂肪细胞中的脂肪分解。我们的结果表明，白藜芦醇通过高剂量诱导细胞毒性具有抗肥胖作用，并且在低浓度下会影响前脂肪细胞的分化和成熟脂肪细胞的脂解作用。

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