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Apoptosis in Thyroid Diseases

机译：甲状腺疾病中的细胞凋亡

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References(39) Cited-By(34) Recent studies demonstrate that apoptosis is an important process in physiological and pathological cell death. We examined the apoptotic phenomena in thyroid tissues by two methods: immunohistological and in situ end-labeling of fragmented DNA (ISEL). In thyroid tissues from patients with Hashimoto's thyroiditis and thyroid cancer, fragmented nuclear DNA and LeY (apoptosis associated antigen) were observed. In tissues from patients with Graves' disease, LeY and bcl-2 oncoprotein were expressed, but no ISEL positive cells were observed. In contrast, thyrocytes in normal thyroid tissues were not stained with ISEL or anti-LeY antibodies (Abs). Fas antigen (Ag) was expressed in various thyroid tissues, including normal subjects. The clinical meaning of this was not determined. These results suggest that the apoptotic process takes place in Hashimoto's thyroiditis and thyroid cancer, and is overcome in Graves' disease by bcl-2 expression.
机译：参考文献（39）Cited-By（34）最近的研究表明，凋亡是生理和病理细胞死亡的重要过程。我们通过两种方法检查了甲状腺组织中的凋亡现象：免疫组织学和片段化DNA的原位末端标记（ISEL）。在桥本甲状腺炎和甲状腺癌患者的甲状腺组织中，观察到碎片的核DNA和LeY（凋亡相关抗原）。在患有Graves病的患者的组织中，表达了LeY和bcl-2癌蛋白，但未观察到ISEL阳性细胞。相反，正常甲状腺组织中的甲状腺细胞未用ISEL或抗LeY抗体（Abs）染色。 Fas抗原（Ag）在各种甲状腺组织中表达，包括正常人。其临床意义尚未确定。这些结果表明，凋亡过程发生在桥本氏甲状腺炎和甲状腺癌中，而在Graves病中通过bcl-2表达得以克服。

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