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首页> 外文期刊>Endocrine journal >Effects of 2 Years' Treatment of Osteoporosis with 1α-Hydroxy Vitamin D3 on Bone Mineral Density and Incidence of Fracture: A Placebo-Controlled, Double-Blind Prospective Study
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Effects of 2 Years' Treatment of Osteoporosis with 1α-Hydroxy Vitamin D3 on Bone Mineral Density and Incidence of Fracture: A Placebo-Controlled, Double-Blind Prospective Study

机译：1α-羟基维生素D3治疗骨质疏松症2年对骨矿物质密度和骨折发生率的影响：安慰剂对照的双盲前瞻性研究

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References(22) Cited-By(30) A two-year double-blind study monitored and evaluated the effects of 1α-hydroxy vitamin D3 (1α(OH)D3) on the lumbar (L2-4BMD) and total body bone mineral densities (TBBMD) and occurrence of fracture in 113 female osteoporotic patients receiving 0.75μg/day of 1α(OH)D3 (n=57) or a placebo (n=56) with calcium supplementation in both groups. L2-4BMD increased 1.81% and 2.32% after one and 2 years in the 1α(OH)D3 group, but decreased 1.89% (P0.05) and 0.28% in the placebo group. A significant difference (P0.01) existed between the two groups after one year. TBBMD decreased significantly in the placebo group by 3.34% (P0.01) and 3.52% after one and 2 years. Six new fractures occurred in the control group, but only two in the 1α(OH)D3 group (Odd's ratio=0.343, 95% confidence range; 0.0648-1.815). There were no serious adverse effects of the 1α(OH)D3 treatment. It was concluded that two-year treatment with 1α(OH)D3 increased the lumbar BMD and inhibited the decrease in TBBMD. Altough it was not significant, new fracture occurrence in the 1α(OH)D3 group was around 1/3 of that in the control group.
机译：参考文献（22）被引至（30）一项为期两年的双盲研究监测并评估了1α-羟基维生素D3（1α（OH）D3）对腰椎（L2-4BMD）和全身骨矿物质密度的影响（TBBMD）和113例女性骨质疏松患者的骨折发生率，两组均接受0.75μg/天的1α（OH）D3（n = 57）或安慰剂（n = 56）。 1α（OH）D3组在1年和2年后L2-4BMD升高1.81％和2.32％，而在安慰剂组中L2-4BMD降低1.89％（P <0.05）和0.28％。一年后，两组之间存在显着差异（P <0.01）。一年和两年后，安慰剂组的TBBMD显着降低3.34％（P <0.01）和3.52％。对照组中发生了6处新的骨折，但1α（OH）D3组中只有2处（Odd's ratio = 0.343，95％置信范围; 0.0648-1.815）。 1α（OH）D3治疗没有严重的不良反应。结论是，两年用1α（OH）D3治疗可增加腰椎BMD并抑制TBBMD的降低。尽管不明显，但1α（OH）D3组新骨折发生率约为对照组的1/3。

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