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首页> 外文期刊>Endocrine journal >Differential Changes of Corticotropin Releasing Hormone (CRH) Concentrations in Plasma and Synovial Fluids of Patients with Rheumatoid Arthritis (RA)
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Differential Changes of Corticotropin Releasing Hormone (CRH) Concentrations in Plasma and Synovial Fluids of Patients with Rheumatoid Arthritis (RA)

机译：类风湿关节炎（RA）患者血浆和滑液中促肾上腺皮质激素释放激素（CRH）浓度的差异变化

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References(24) Cited-By(5) Corticotropin releasing hormone (CRH) and ACTH concentrations in plasma and CRH and IL-6 concentrations in synovial fluid in patients with rheumatoid arthritis (RA) were examined to clarify the relationship between cytokines and the hypothalamic-pituitary-adrenal axis (HPA axis). Concentrations of serum amyloid A protein (SAA), one of the acute phase proteins, were also measured as an indicator of inflammation. CRH and IL-6 concentrations in synovial fluid were higher in RA patients than in control patients (osteoarthritis, OA). Plasma ACTH and CRH levels were significantly lower in RA patients than in OA patients. This suggests that CRH secretion in synovial fluid is regulated differently from plasma CRH secretion, as CRH levels in synovial fluid and plasma showed opposite changes in RA patients. SAA levels were positively correlated with the levels of CRH or IL-6 in synovial fluid, whereas there was no correlation between CRH and IL-6 levels. The results suggest that CRH and IL-6 play important independent roles in producing SAA in synovial fluid.
机译：参考文献（24）引用了By（5）的类风湿关节炎（RA）患者血浆中促肾上腺皮质激素释放激素（CRH）和ACTH浓度以及滑液中CRH和IL-6浓度，以阐明细胞因子与下丘脑之间的关系-垂体-肾上腺轴（HPA轴）。还测量了血清淀粉样蛋白A蛋白（SAA）（一种急性期蛋白）的浓度，作为炎症的指标。 RA患者滑膜液中CRH和IL-6的浓度高于对照组（骨关节炎，OA）。 RA患者的血浆ACTH和CRH水平显着低于OA患者。这表明滑膜液中CRH分泌的调节与血浆CRH分泌不同，因为滑膜液和血浆中的CRH水平在RA患者中表现出相反的变化。滑膜液中SAA水平与CRH或IL-6水平呈正相关，而CRH与IL-6水平之间无相关性。结果表明CRH和IL-6在滑液中产生SAA中起着重要的独立作用。

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