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首页> 外文期刊>Endocrine journal >Insulin-Like Growth Factors (IGFs) and IGF-Binding Proteins (IGFBP-1, -2 and -3) in Diabetic Pregnancy: Relationship to Macrosomia
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Insulin-Like Growth Factors (IGFs) and IGF-Binding Proteins (IGFBP-1, -2 and -3) in Diabetic Pregnancy: Relationship to Macrosomia

机译：糖尿病妊娠中胰岛素样生长因子（IGFs）和IGF结合蛋白（IGFBP-1，-2和-3）：与巨人症的关系

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References(45) Cited-By(9) To evaluate the role of insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in exessive fetal growth (macrosomia) in diabetic pregnancy, 84 insulin-treated diabetic mothers and their infants were tested for serum concentrations of IGF-I, IFG-II, and IGFBP-1, -2 and -3. These parameters were correlated with the birth weight of neonates and placental weight. IGF-I and II levels were determined by specific radioimmunoassays (RIAs) after serum samples were extracted with aid-ethanol. IGFBPs were measured by Western immunoblot with specific antibodies to the respective IGFBP species. Serum concentrations of both IGF-I and IGF-II in mothers with either IDDM or NIDDM increased with the gestational period, reached a plateau at the third trimester, and returned to non-pregnant levels within 7 days after delivery. These values were not different from those in normal mothers before and throughout pregnancy. As previously reported, IGF-I concentrations in cord serum of neonates born to diabetic mothers were (P0.01) higher than those of newborns of normal mothers. Likewise, cord blood IGF-II levels were 2-fold higher in babies of diabetic mothers (P0.001). Fetal IGF-I and IGF-II correlated with each other and with maternal HbA1C, and they positively correlated with either birth weight or placental weight. Cord IGFBP-3 concentrations were significantly higher in diabetic pregnancy, but IGFBP-2 concentrations were not different from those in normal pregnancy. Cord IGFBP-1 concentrations were significantly higher only in babies of mothers with IDDM. None of these cord IGFBP concentrations correlated with birth weight or placental weight. The data suggest that fetal IGF-II, like IGF-I, is involved in fetal and placental growth in diabetic pregnancy. The role of IGFBPs remained to be determined.
机译：参考文献（45）被引用（9）为了评估胰岛素样生长因子（IGF）和IGF结合蛋白（IGFBPs）在糖尿病妊娠中84名接受胰岛素治疗的糖尿病母亲及其胎儿中的作用。测试了婴儿的IGF-I，IFG-II和IGFBP-1，-2和-3的血清浓度。这些参数与新生儿的出生体重和胎盘重量相关。在用辅助乙醇提取血清样品后，通过特异性放射免疫测定法（RIA）测定IGF-I和II的水平。通过Western免疫印迹用针对各个IGFBP种类的特异性抗体测量IGFBP。具有IDDM或NIDDM的母亲的血清IGF-I和IGF-II浓度均随着妊娠期的增加而增加，在孕晚期达到平稳，并在分娩后7天内恢复到非妊娠水平。这些值与正常母亲在怀孕前和整个怀孕期间的值没有不同。如先前报道，糖尿病母亲出生的新生儿脐带血清中的IGF-1浓度高于正常母亲的新生儿（P <0.01）。同样，糖尿病母亲的婴儿脐带血IGF-II水平高2倍（P <0.001）。胎儿的IGF-I和IGF-II相互关联，并且与母亲的HbA1C关联，并且与出生体重或胎盘重量呈正相关。糖尿病妊娠的脐带IGFBP-3浓度明显升高，但IGFBP-2浓度与正常妊娠无差异。脐带IGFBP-1浓度仅在IDDM母亲的婴儿中显着较高。这些脐带IGFBP浓度均与出生体重或胎盘重量无关。数据表明，与IGF-I一样，胎儿IGF-II与糖尿病妊娠中胎儿和胎盘的生长有关。 IGFBP的作用尚待确定。

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