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首页> 外文期刊>Endocrine journal >Short Term Treatment with Different Doses of Human Growth Hormone in Adult Patients with Growth Hormone Deficiency
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Short Term Treatment with Different Doses of Human Growth Hormone in Adult Patients with Growth Hormone Deficiency

机译：成年生长激素缺乏症患者不同剂量人生长激素的短期治疗

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References(23) Cited-By(1) We studied the effects of short term replacement with human GH at three doses (0.124, 0.250 and 0.375IU/kgBW/week) in 12 adult patients with GH deficiency (GHD). The patients were divided at random into three goups of 4 patients (groups A, B and C) and each group was treated with three doses of GH and placebo for 10 weeks in shifts of two weeks each. The replacement was started with one of three doses of GH given sc daily at 2100h for 2 weeks, which was followed by placebo treatment for 2 weeks. The various doses of GH and placebo were then given alternately. GH treatment increased serum IGF-I and IGF-BP3 levels in all the patients examined although the responses were partly influenced by the order of GH treatment. When the data obtained with the same doses of GH in the three groups were combined, a dose-response was demonstrated. There was a close correlation (r=0.726) between serum IGF-I and IGFBP-3. Serum triiodothyronine as well as non-esterified fatty acid (NEFA) levels also increased after GH replacement. Adverse side effects included edema in two cases and sleep distress in one case during the GH treatment at the highest dose of 0.375IU/kgBW/week. These findings indicate that short term replacement with GH at the doses of 0.125 and 0.250IU/kgBW/week is safe and effective in adult patients with GHD.
机译：参考文献（23）By-By（1）我们研究了12例成年GH缺乏症（GHD）成年患者的三种剂量（0.124、0.250和0.375IU / kgBW /周）短期用人类GH替代治疗的效果。将患者随机分为三组，每组4名患者（A，B和C组），每组分别接受三剂量的GH和安慰剂治疗，每两周轮换10周。每天2100h皮下注射三剂GH之一开始替代治疗，持续2周，然后进行安慰剂治疗2周。然后交替给予各种剂量的GH和安慰剂。 GH治疗增加了所有检查患者的血清IGF-I和IGF-BP3水平，尽管反应部分受到GH治疗顺序的影响。当将三组中相同剂量的GH获得的数据合并在一起时，就证明了剂量反应。血清IGF-1和IGFBP-3之间存在密切的相关性（r = 0.726）。 GH替代后，血清三碘甲状腺素和非酯化脂肪酸（NEFA）的水平也增加了。不良反应包括2例水肿和1例在GH治疗期间以0.375IU / kgBW /周的最高剂量进行睡眠困扰。这些发现表明，在成年的GHD患者中，以0.125和0.250IU / kgBW /周的剂量短期替换GH是安全有效的。

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