...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Endoscopy International Open >Tumor location is a risk factor for lymph node metastasis in superficial Barrett’s adenocarcinoma
【24h】

Tumor location is a risk factor for lymph node metastasis in superficial Barrett’s adenocarcinoma

机译：肿瘤的位置是浅表巴雷特腺癌淋巴结转移的危险因素

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background and study aims Endoscopic treatment is indicated for superficial Barrett’s adenocarcinoma (BA) with a negligible risk of lymph node metastasis (LNM). However, risk factors associated with LNM in superficial BA are still not well characterized. The aim of the current study was to clarify risk factors for LNM of superficial BA. Patients and methods A retrospective study was conducted in 87 consecutive patients with BA that was resected at National Cancer Center Hospital, Tokyo, Japan between 1990 and 2013. We assessed tumor size, macroscopic type, histological type, tumor depth of invasion, lymphovascular invasion and tumor location to analyze factors associated with LNM. Tumor location was classified into following 2 groups according to Siewert classification: 1) BA of the esophagogastric junction (EGJ-BA) as those having their center within 1?cm proximal from the EGJ; and 2) Esophageal-BA as those having their center at 1?cm or more proximal to the EGJ. EGJ was defined as distal end of the palisade vessels. Results LNM was detected in 10 (11?%) patients. Univariable analysis revealed that tumor size, tumor depth of invasion, histological type of mixed differentiated and undifferentiated-type adenocarcinoma, lymphovascular invasion and tumor location of esophageal-BA were significantly associated with LNM. Multivariable analysis revealed that tumor location of esophageal-BA [odds ratio 7.8 (95?%CI: 1.3?–?48.1)] was a potential risk factor for LNM. Conclusions The current study demonstrated that tumor location is a potential risk factor for LNM in BA. Therefore, indications for endoscopic treatment of esophageal-BA and EGJ-BA could be different.
机译：背景和研究目的内镜治疗适用于浅表巴雷特氏腺癌（BA），淋巴结转移（LNM）的风险可忽略不计。但是，与浅表性BA中LNM相关的危险因素仍没有很好的特征。本研究的目的是阐明浅层BA LNM的危险因素。患者和方法对1990年至2013年在日本东京国立癌症中心医院切除的87例BA进行了回顾性研究。我们评估了肿瘤的大小，宏观类型，组织学类型，肿瘤浸润深度，淋巴管浸润和肿瘤位置分析与LNM相关的因素。根据Siewert分类，将肿瘤位置分为以下两类：1）食管胃交界处的BA（EGJ-BA），其中心位于EGJ附近1？cm以内。 2）食管BA：其中心位于EGJ附近1？cm或更大。 EGJ被定义为木栅血管的远端。结果10例患者中检出LNM（11％）。单因素分析显示，肿瘤大小，浸润深度，混合分化和未分化型腺癌的组织学类型，淋巴管浸润和食管BA的肿瘤位置均与LNM显着相关。多变量分析显示，食管BA的肿瘤位置[比值7.8（95 %% CI：1.3？-48.1）]是LNM的潜在危险因素。结论当前的研究表明，肿瘤位置是BA中LNM的潜在危险因素。因此，内镜治疗食管BA和EGJ-BA的适应症可能有所不同。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号