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首页> 外文期刊>Endocrine journal >Identification of Somatotrophs, Mammosomatotrophs, and Mammotrophs by Sandwich Cell Immunoblot Assay in GH- Secreting Adenomas and Prolactinomas: Correlations between the Proportions of Hormone Secreting Cells and Tumor Size
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Identification of Somatotrophs, Mammosomatotrophs, and Mammotrophs by Sandwich Cell Immunoblot Assay in GH- Secreting Adenomas and Prolactinomas: Correlations between the Proportions of Hormone Secreting Cells and Tumor Size

机译：在分泌GH的腺瘤和泌乳素瘤中通过夹心细胞免疫印迹法鉴定造胃菌，哺乳类营养菌和哺乳类营养菌：激素分泌细胞比例与肿瘤大小之间的相关性

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References(38) Cited-By(3) Sandwich cell Immunoblot assay(sandwich CIBA) was used to identify somatotrophs (GH cells), mammosomatotrophs, and mammotrophs (PRL cells) in pituitary tumors obtained from patients with GH-secreting adenomas and prolactinomas. The mean serum GH level was 177.6ng/ml in 19 patients with GH-secreting adenomas and the mean PRL level was 2, 129ng/ml in 9 patients with prolactinomas. GH-secreting adenomas could be divided into 3 groups according to the proportions of the cell types. The GH cell dominant type had more than 70% GH cells. The mammosomatotroph cell dominant type had more than 80% mammosomatotrophs. The nondominant type had no dominant cell type. There was a good correlation (r2=0.804) between serum GH levels and tumor size in patients with the GH cell dominant type (n=10). The nondominant type (n=8) had a low serum level of GH except for one tumor. The mammosomatotroph cell dominant type (n=1) showed high serum levels of both GH and PRL. All prolactinomas had a predominance of PRL cells. Sandwich CIBA is a simple method for detecting GH cells, mammosomatotrophs, and PRL cells, and useful for classification for GH-secreting adenomas.
机译：参考文献（38）被引用的By（3）夹心细胞免疫印迹法（夹心CIBA）用于鉴定垂体瘤中自分泌GH的腺瘤和泌乳素瘤患者获得的体细胞营养素（GH细胞），乳腺营养体营养素和乳腺营养体（PRL细胞）。 19例分泌GH的腺瘤患者的平均血清GH水平为177.6ng / ml，9例催乳素瘤患者的平均PRL水平为2，129ng / ml。根据细胞类型的比例，分泌GH的腺瘤可分为3组。 GH细胞优势型具有超过70％的GH细胞。哺乳动物营养缺陷型细胞占主导地位的类型有超过80％的哺乳动物营养缺陷型。非显性类型没有显性细胞类型。 GH细胞优势型（n = 10）患者的血清GH水平与肿瘤大小之间存在良好的相关性（r2 = 0.804）。非优势型（n = 8）除一个肿瘤外血清GH水平低。乳腺营养型细胞优势型（n = 1）显示出高血清GH和PRL水平。所有泌乳素瘤均以PRL细胞为主。夹层CIBA是检测GH细胞，乳腺营养细胞和PRL细胞的简单方法，可用于分类分泌GH的腺瘤。

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