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首页> 外文期刊>Engineering Letters >Modeling the Effect of Bed Height and Particle Size for Vitamin K2 Production in a Static Bed Fermenter
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Modeling the Effect of Bed Height and Particle Size for Vitamin K2 Production in a Static Bed Fermenter

机译：模拟静态床发酵罐中床高和粒度对维生素K2生产的影响

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Soy granules were used as a substrate for microbialproduction of Vitamin K2 using Bacillus subtilis. Static bed“tray type” fermentation was carried out and the operation ofthis fermentation was optimized using full factorial statisticalmethod of analysis. The optimum parameters were obtainedas: bed thickness; particle size, incubation time. The resultsindicated that the MK7 yield reductions caused by elevated bedheights were reduced considerably with the correspondingelevations in particle sizes by improved substrate porosity. Thepolynomial model fitted the experimental data well with R2 =0.85 and R2 (adj) = 0.78. MK7 production was increased from104.1 mg/kg to 106.4±2.1 mg/kg when the strain wascultivated at optimum conditions predicted by statisticalapproach (50 mm bed thickness, 1-1.4 mm particle size, 8 daysincubation time). The results of this investigation via statisticalmodeling of solid state fermentations assist to build aframework for quantitative and mechanistic fermentationdesign. They present a challenge for scale up.
机译：大豆颗粒用作使用枯草芽孢杆菌微生物生产维生素K2的底物。进行了静态床“托盘式”发酵，并使用全因子统计分析方法优化了该发酵的操作。获得的最佳参数为：床层厚度;粒径，孵育时间。结果表明，由于提高的底重而导致的MK7收率降低显着降低，同时由于提高了基质孔隙率，相应地提高了粒度。多项式模型很好地拟合了实验数据，R2 = 0.85，R2（adj）= 0.78。在通过统计学方法（50 mm床厚，1-1.4 mm粒径，8天孵育时间）预测的最佳条件下培养菌株时，MK7产量从104.1 mg / kg增加到106.4±2.1 mg / kg。通过固态发酵的统计模型进行的这项研究的结果有助于建立定量和机械发酵设计的框架。他们提出了扩大规模的挑战。

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