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首页> 外文期刊>Environmental health perspectives. >Survival Analysis of Long-Term Exposure to Different Sizes of Airborne Particulate Matter and Risk of Infant Mortality Using a Birth Cohort in Seoul, Korea
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Survival Analysis of Long-Term Exposure to Different Sizes of Airborne Particulate Matter and Risk of Infant Mortality Using a Birth Cohort in Seoul, Korea

机译：韩国首尔的一个出生队列对长期暴露于不同大小的空气传播颗粒物质和婴儿死亡风险的生存分析

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Background Several studies suggest that airborne particulate matter (PM) is associated with infant mortality; however, most focused on short-term exposure to larger particles. Objectives We evaluated associations between long-term exposure to different sizes of particles [total suspended particles (TSP), PM ≤ 10 μm in aerodynamic diameter (PM10), ≤ 10–2.5 μm (PM10–2.5), and ≤ 2.5 μm (PM2.5)] and infant mortality in a cohort in Seoul, Korea, 2004–2007. Methods The study includes 359,459 births with 225 deaths. We applied extended Cox proportional hazards modeling with time-dependent covariates to three mortality categories: all causes, respiratory, and sudden infant death syndrome (SIDS). We calculated exposures from birth to death (or end of eligibility for outcome at 1 year of age) and pregnancy (gestation and each trimester) and treated exposures as time-dependent variables for subjects’ exposure for each pollutant. We adjusted by sex, gestational length, season of birth, maternal age and educational level, and heat index. Each cause of death and exposure time frame was analyzed separately. Results We found a relationship between gestational exposures to PM and infant mortality from all causes or respiratory causes for normal-birth-weight infants. For total mortality (all causes), risks were 1.44 (95% confidence interval, 1.06–1.97), 1.65 (1.18–2.31), 1.53 (1.22–1.90), and 1.19 (0.83–1.70) per interquartile range increase in TSP, PM10, PM2.5, and PM10–2.5, respectively; for respiratory mortality, risks were 3.78 (1.18–12.13), 6.20 (1.50–25.66), 3.15 (1.26–7.85), and 2.86 (0.76–10.85). For SIDS, risks were 0.92 (0.33–2.58), 1.15 (0.38–3.48), 1.42 (0.71–2.87), and 0.57 (0.16–1.96), respectively. Conclusions Our findings provide supportive evidence of an association of long-term exposure to PM air pollution with infant mortality.
机译：背景多项研究表明，空气中的颗粒物（PM）与婴儿死亡率有关。然而，大多数集中在短期接触较大颗粒。目的我们评估了长期暴露于不同尺寸的颗粒之间的关联[总悬浮颗粒（TSP），空气动力学直径PM≤10μm（PM 10 ），≤10–2.5μm（PM 10–2.5 ）和≤2.5μm（PM 2.5 ）]和婴儿死亡率。方法：该研究包括359,459例婴儿，其中225例死亡。我们将时间相关协变量的扩展Cox比例风险建模应用于三个死亡率类别：所有原因，呼吸系统疾病和婴儿猝死综合症（SIDS）。我们计算了从出生到死亡（或1岁时结局的资格终止）和怀孕（妊娠和每个妊娠三个月）的暴露，并将暴露作为受试者对每种污染物的暴露的时间依赖性变量。我们根据性别，胎龄，出生季节，产妇年龄和受教育程度以及发热量指数进行了调整。分别分析了每个死亡原因和暴露时间范围。结果我们发现孕期PM暴露与正常出生体重婴儿的各种原因或呼吸道原因引起的婴儿死亡率之间存在关联。对于总死亡率（所有原因），TSP每增加四分位数，风险分别为1.44（95％置信区间1.06-1.97），1.65（1.18-2.31），1.53（1.22-1.90）和1.19（0.83-1.70）， PM 10 ，PM 2.5 和PM 10–2.5 ;呼吸道疾病的风险分别为3.78（1.18–12.13），6.20（1.50–25.66），3.15（1.26-7.85）和2.86（0.76–10.85）。对于小岛屿发展中国家，风险分别为0.92（0.33-2.58），1.15（0.38-3.48），1.42（0.71-2.87）和0.57（0.16-1.96）。结论我们的发现为长期暴露于PM空气污染与婴儿死亡率之间的关系提供了支持性证据。

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