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首页> 外文期刊>Epigenetics & Chromatin >Sex-specific chromatin states in mammalian fetal germ cells
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Sex-specific chromatin states in mammalian fetal germ cells

机译：哺乳动物胎儿生殖细胞中的性别特异性染色质状态

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摘要

Male and female mammalian germ cells follow identicaldevelopmental trajectories for the first half of embryogenesis,during which time they also maintain a pluripotentlikestate. Beginning around day 13.5 of embryogenesis(E13.5), male and female germ cells initiate dramaticallydifferent developmental programs: female germ cells entermeiotic prophase, while male germ cells enter a G0-likecell cycle arrest until after birth [1]. At this time, bothmale and female germ cells also lose the ability to establishpluripotent cell lines in culture [2]. As late as E12.5, maleand female germ cells are morphologically identical, andfew transcriptional differences can be detected [1,3]. Toevaluate the coordination of sex-specific transcriptionalstates during this important interval in germ cell differentiation,we examined placement of the activating histonemodification H3K4me3 and the repressive histone modificationH3K27me3 in XX and XY murine germ cells beforeand during the initiation of sex differentiation.
机译：雄性和雌性哺乳动物生殖细胞在胚胎发生的前半部分遵循相同的发育轨迹，在此期间它们还保持着多能样状态。从胚胎发生的第13.5天（E13.5）开始，雄性和雌性生殖细胞启动了截然不同的发育程序：雌性生殖细胞进入减数分裂前期，而雄性生殖细胞进入G0样细胞周期停滞直至出生[1]。此时，雄性和雌性生殖细胞也都失去了在培养物中建立多能细胞系的能力[2]。直到E12.5，雄性和雌性生殖细胞在形态上都是相同的，几乎没有转录差异[1,3]。为了评估生殖细胞分化这一重要间隔期间性别特异性转录状态的协调性，我们研究了性别分化开始之前和期间，XX和XY鼠生殖细胞中激活组蛋白修饰H3K4me3和阻抑组蛋白修饰H3K27me3的位置。

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