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首页> 外文期刊>Epigenetics & Chromatin >DNA methylation and gene expression patterns in breast cancer progression from in situ carcinoma to invasive carcinoma
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DNA methylation and gene expression patterns in breast cancer progression from in situ carcinoma to invasive carcinoma

机译：乳腺癌从原位癌向浸润性癌进展中的DNA甲基化和基因表达模式

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Breast cancer is a disease caused by uncontrolled celldivision of epithelial cells in the ducts or the lobules ofthe breast. The ducts and lobules are enclosed by abasement membrane, and during progression of the diseasethe invading cells will breach the membrane andinvade adjacent tissue. A tumor that is still enclosed inthe basement membrane is called a carcinoma in situ,while a tumor that has breached the basement membraneis called an invasive carcinoma. DNA methylationis a DNA modification where methyl groups are addedto CpG dinucleotides and thought to regulate geneexpression through blocking of transcription factorbinding or through chromatin remodeling. The aim ofthe study was to determine what genes get differentiallymethylated when the cancer progresses from a less to amore aggressive carcinoma. In addition, by applyingintegrated analysis of other molecular data such as geneexpression and copy number, we could investigate howmore elaborate biological processes change during progression.Being able to determine the processes thattake place during progression of breast cancer may givevaluable insight into cancer biology, as well as identificationof early markers of disease.
机译：乳腺癌是由乳房的导管或小叶中的上皮细胞不受控制的细胞分裂引起的疾病。导管和小叶被基底膜包围，在疾病进展期间，侵入的细胞将突破膜并侵入邻近组织。仍然封闭在基底膜中的肿瘤称为原位癌，而破坏基底膜的肿瘤则称为浸润性癌。 DNA甲基化是一种DNA修饰，其中甲基被添加到CpG二核苷酸中，并被认为通过阻断转录因子结合或染色质重塑来调节基因表达。该研究的目的是确定当癌症从侵袭性较小的癌症发展为更具侵略性的癌症时，哪些基因差异甲基化。此外，通过对其他分子数据（例如基因表达和拷贝数）进行综合分析，我们可以研究进展过程中复杂的生物学过程变化。能够确定乳腺癌进展过程中发生的过程可能对癌症生物学也有宝贵的见解。作为疾病早期标志物的鉴定。

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