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Mitotic bookmarking by transcription factors

机译：有丝分裂书签转录因子

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Mitosis is accompanied by dramatic changes in chromatin organization and nuclear architecture. Transcription halts globally and most sequence-specific transcription factors and co-factors are ejected from mitotic chromatin. How then does the cell maintain its transcriptional identity throughout the cell division cycle? It has become clear that not all traces of active transcription and gene repression are erased within mitotic chromatin. Many histone modifications are stable or only partially diminished throughout mitosis. In addition, some sequence-specific DNA binding factors have emerged that remain bound to select sites within mitotic chromatin, raising the possibility that they function to transmit regulatory information through the transcriptionally silent mitotic phase, a concept that has been termed “mitotic bookmarking.” Here we review recent approaches to studying potential bookmarking factors with regards to their mitotic partitioning, and summarize emerging ideas concerning the in vivo functions of mitotically bound nuclear factors.
机译：有丝分裂伴随着染色质组织和核结构的急剧变化。转录整体停止，并且大多数有序列特异性的转录因子和辅因子从有丝分裂染色质中弹出。那么细胞如何在整个细胞分裂周期中保持其转录身份？已经清楚的是，在有丝分裂染色质中并非所有活性转录和基因抑制的痕迹都被消除。在整个有丝分裂中，许多组蛋白修饰是稳定的或仅部分减弱。此外，已经出现了一些序列特异性DNA结合因子，这些因子仍与有丝分裂染色质内的选定位点结合，从而增加了它们通过转录沉默有丝分裂相传递调控信息的可能性，这一概念被称为“有丝分裂书签”。在这里，我们审查有关其有丝分裂分区研究潜在的书签因素的最新方法，并总结有关有丝分裂结合核因子的体内功能的新兴思想。

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