Transcriptome dysregulation and epigenome signature responses in hepatocytes upon hepatitis B virus infection and therapy

Andreas Klein; Lisa Wiluhn; Theodor Winkler; Timo Deba; Valerie Orth; Kai Hensel; Andreas Jenke; Stefan Wirth; Jan Postberg

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Transcriptome dysregulation and epigenome signature responses in hepatocytes upon hepatitis B virus infection and therapy

机译：乙型肝炎病毒感染和治疗后肝细胞转录组失调和表观基因组签名反应

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Chronic infection with hepatitis B virus (HBV) inducestransregulation of the host cell gene expression and eventuallymalignant transformation. HBV X protein acts as atransactivator of cellular promoters leading to upregulationof DNA methyltransferases and alterations of DNAmethylation patterns.

机译：乙型肝炎病毒（HBV）的慢性感染诱导宿主细胞基因表达的调控和最终的恶性转化。 HBV X蛋白作为细胞启动子的反式激活因子，导致DNA甲基转移酶的上调和DNA甲基化模式的改变。

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《Epigenetics & Chromatin》 |2013年第1期|共页
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Andreas Klein; Lisa Wiluhn; Theodor Winkler; Timo Deba; Valerie Orth; Kai Hensel; Andreas Jenke; Stefan Wirth; Jan Postberg;
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5. Hepatitis C virus infection: Racial differences in presentation, progression and response to therapy. [D] . Ataher, Quazi S. 2006

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6. Transcriptome dysregulation and epigenome signature responses in hepatocytes upon hepatitis B virus infection and therapy [O] . Andreas Klein, Lisa Wiluhn, Theodor Winkler, 2013

机译：乙型肝炎病毒感染和治疗后肝细胞转录组失调和表观基因组签名反应
7. Transcriptome dysregulation and epigenome signature responses in hepatocytes upon hepatitis B virus infection and therapy [O] . 2013

机译：乙型肝炎病毒感染和治疗后肝细胞转录组失调和表观基因组签名反应

Transcriptome dysregulation and epigenome signature responses in hepatocytes upon hepatitis B virus infection and therapy

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