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首页> 外文期刊>Epigenetics & Chromatin >Asymmetric cell division via DNA strand-specific epigenetic imprinting and segregation explains eukaryotic development
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Asymmetric cell division via DNA strand-specific epigenetic imprinting and segregation explains eukaryotic development

机译：通过DNA链特异性表观遗传印迹和分离的不对称细胞分裂解释了真核生物的发育

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The asymmetric cell division is crucial during developmentand to produce self-renewing stem cells. A largebody of work on Drosophila and C. elegans suggests thatthis process occurs by non-equivalent distribution of proteinsand/or mRNA (intrinsic factors) to daughter cells, orby their differential exposure to cell extrinsic factors. Incontrast, strictly based on template “Watson” versus“Crick” strand inherited from the parental cell, haploid fissionyeast sister cells developmentally differ by inheritingsister chromatids that are differentiated by epigeneticmeans. Specifically, the double helical structure of DNA isthe ultimate determinant of asymmetric cell division. Toemploy this kind of mechanism for cellular differentiationin diploid organisms, selective segregation must occur forpartitioning epigenetically differentiated sister chromatidsfrom both chomosome homologs to specific daughtercells, at a specific cell division, during multicelluar organismdevelopment. We previously proposed that SomaticSister chromatid Imprinting and Selective chromatid Segregation(SSIS) model might explain development ineukaryotes, such as that of the body left-right axis lateralityspecification in mice and brain laterality in humans. However,for technical reasons, it is impossible to determinewhether such a mechanism operates during embryonicdevelopment in higher organisms.
机译：不对称细胞分裂在发育和产生自我更新干细胞过程中至关重要。果蝇和秀丽隐杆线虫的大量研究表明，这一过程是通过蛋白质和/或mRNA（内在因子）在子细胞中的非等价分布，或通过它们对细胞外在因子的不同暴露而发生的。相反，严格基于从亲代细胞遗传的模板“ Watson”对“ Crick”链，单倍体裂变酵母姊妹细胞通过遗传由表观遗传学手段分化的姐妹染色单体而在发育上有所不同。具体而言，DNA的双螺旋结构是不对称细胞分裂的最终决定因素。为了在二倍体生物体中采用这种细胞分化机制，必须在多细胞生物体发育过程中发生选择性分离，以将表观遗传分化的姐妹染色单体从两个染色体同源物分配到特定子细胞，并在特定的细胞分裂中进行分配。我们以前曾提出SomaticSister染色单体印迹和选择性染色单体分离（SSIS）模型可以解释发育中的真核生物，例如小鼠体内的左右轴偏侧性规范和人类的大脑侧偏性。但是，由于技术原因，无法确定这种机制在高等生物的胚胎发育过程中是否起作用。

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