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首页> 外文期刊>Environmental Health: A Global Access Science Source >Perturbation of lipids and glucose metabolism associated with previous 2,4-D exposure: a cross-sectional study of NHANES III data, 1988-1994
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Perturbation of lipids and glucose metabolism associated with previous 2,4-D exposure: a cross-sectional study of NHANES III data, 1988-1994

机译：与以前的2,4-D暴露相关的脂质和葡萄糖代谢的扰动：NHANES III数据的横断面研究，1988-1994年

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Background Results from previous population studies showed that mortality rates from acute myocardial infarction and type-2 diabetes during the 1980s and 1990s in rural, agricultural counties of Minnesota, Montana, North and South Dakota, were higher in counties with a higher level of spring wheat farming than in counties with lower levels of this crop. Spring wheat, one of the major field crops in these four states, was treated for 85% or more of its acreage with chlorophenoxy herbicides. In the current study NHANES III data were reviewed for associations of 2,4-dichlorophenoxy acetic acid (2,4-D) exposure, one of the most frequently used chlorophenoxy herbicides, with risk factors that are linked to the pathogenesis of acute myocardial infarction and type-2 diabetes, such as dyslipidemia and impaired glucose metabolism. Methods To investigate the toxicity pattern of chlorophenoxy herbicides, effects of a previous 2,4-D exposure were assessed by comparing levels of lipids, glucose metabolism, and thyroid stimulating hormone in healthy adult NHANES III subjects with urinary 2,4-D above and below the level of detection, using linear regression analysis. The analyses were conducted for all available subjects and for two susceptible subpopulations characterized by high glycosylated hemoglobin (upper 50th percentile) and low thyroxine (lower 50th percentile). Results Presence of urinary 2,4-D was associated with a decrease of HDL levels: 8.6% in the unadjusted data (p-value = 0.006), 4.8% in the adjusted data (p-value = 0.08), and 9% in the adjusted data for the susceptible subpopulation with low thyroxine (p-value = 0.02). An effect modification of the inverse triglycerides-HDL relation was observed in association with 2,4-D. Among subjects with low HDL, urinary 2,4-D was associated with increased levels of triglycerides, insulin, C-peptide, and thyroid stimulating hormone, especially in the susceptible subpopulations. In contrast, subjects with high HDL did not experience adverse 2,4-D associated effects. Conclusions The results indicate that exposure to 2,4-D was associated with changes in biomarkers that, based on the published literature, have been linked to risk factors for acute myocardial infarction and type-2 diabetes.
机译：背景先前的人口研究结果显示，明尼苏达州，蒙大拿州，北达科他州和南达科他州的农村，农业县在1980年代和1990年代急性心肌梗死和2型糖尿病的死亡率在春季小麦水平较高的县中较高。农业比这种作物水平较低的县高。春小麦是这四个州的主要田间作物之一，用氯苯氧基除草剂处理了其小麦面积的85％或以上。在当前的研究中，NHANES III数据审查了2,4-二氯苯氧基乙酸（2,4-D）暴露（一种最常用的氯苯氧基除草剂）与危险因素相关的关联，这些危险因素与急性心肌梗死的发病机制有关和2型糖尿病，例如血脂异常和葡萄糖代谢受损。方法为了研究氯苯氧基除草剂的毒性模式，通过比较健康的成年NHANES III尿液高于，高于和高于尿液中的2,4-D受试者的脂质，葡萄糖代谢和甲状腺刺激激素水平，评估了先前2,4-D暴露的影响。低于检测水平，则使用线性回归分析。对所有可用受试者和特征为高糖基化血红蛋白（上部50％）和甲状腺素低（下部50％）的两个易感亚群进行了分析。结果尿中2,4-D的存在与HDL水平的降低有关：未经调整的数据为8.6％（p值= 0.006），经过调整的数据为4.8％（p值= 0.08），而在未调整的数据中为9％。低甲状腺素易感亚群的校正数据（p值= 0.02）。与2，4-D相关地观察到甘油三酸酯-HDL逆关系的效果改变。在低HDL的受试者中，尿中的2,4-D与甘油三酸酯，胰岛素，C肽和甲状腺刺激激素水平的升高有关，尤其是在易感人群中。相反，高HDL的受试者没有经历不利的2，4-D相关作用。结论结果表明，暴露于2,4-D与生物标志物的变化有关，根据已发表的文献，这些标志物与急性心肌梗塞和2型糖尿病的危险因素有关。

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