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首页> 外文期刊>Environmental Health: A Global Access Science Source >Air pollution, fetal and infant tobacco smoke exposure, and wheezing in preschool children: a population-based prospective birth cohort
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Air pollution, fetal and infant tobacco smoke exposure, and wheezing in preschool children: a population-based prospective birth cohort

机译：空气污染，胎儿和婴儿烟草烟雾暴露以及学龄前儿童的喘息：基于人群的预期出生队列

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Background Air pollution is associated with asthma exacerbations. We examined the associations of exposure to ambient particulate matter (PM10) and nitrogen dioxide (NO2) with the risk of wheezing in preschool children, and assessed whether these associations were modified by tobacco smoke exposure. Methods This study was embedded in the Generation R Study, a population-based prospective cohort study among 4,634 children. PM10 and NO2 levels were estimated for the home addresses using dispersion modeling. Annual parental reports of wheezing until the age of 3 years and fetal and infant tobacco smoke exposure was obtained by questionnaires. Results Average annual PM10 or NO2 exposure levels per year were not associated with wheezing in the same year. Longitudinal analyses revealed non-significant tendencies towards positive associations of PM10 or NO2 exposure levels with wheezing during the first 3 years of life (overall odds ratios (95% confidence interval): 1.21 (0.79, 1.87) and 1.06 (0.92, 1.22)) per 10 μg/m3 increase PM10 and NO2, respectively). Stratified analyses showed that the associations were stronger and only significant among children who were exposed to both fetal and infant tobacco smoke (overall odds ratios 4.54 (1.17, 17.65) and 1.85 (1.15, 2.96)) per 10 μg/m3 increase PM10 and NO2, respectively (p-value for interactions <0.05). Conclusions Our results suggest that long term exposure to traffic-related air pollutants is associated with increased risks of wheezing in children exposed to tobacco smoke in fetal life and infancy. Smoke exposure in early life might lead to increased vulnerability of the lungs to air pollution.
机译：背景技术空气污染与哮喘发作有关。我们检查了学龄前儿童接触环境颗粒物（PM10）和二氧化氮（NO2）与喘息风险的关联，并评估了这些关联是否因烟草烟雾暴露而改变。方法该研究被纳入“ Generation R研究”中，该研究是一项基于人群的前瞻性队列研究，涉及4,634名儿童。使用分散模型估算了家庭住址的PM10和NO2含量。通过问卷调查获得了直到3岁为止的喘息年度父母报告以及胎儿和婴儿烟草烟雾暴露。结果同年，每年平均PM10或NO2暴露水平与喘息无关。纵向分析显示，在生命的前3年中，PM10或NO2暴露水平与喘鸣呈正相关的趋势不明显（总体优势比（95％置信区间）：1.21（0.79，1.87）和1.06（0.92，1.22））每10μg/ m3分别增加PM10和NO2）。分层分析表明，每增加10μg/ m3 PM10和NO2，暴露于胎儿和婴儿烟草烟雾（总比值比为4.54（1.17，17.65）和1.85（1.15，2.96））的儿童中，这种关联更强并且更有意义。 ，（交互作用的p值<0.05）。结论我们的结果表明，长期暴露于与交通有关的空气污染物与胎儿生活和婴儿期接触烟草烟雾的儿童发生喘息的风险增加有关。早年接触烟雾可能导致肺部更易受到空气污染。

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