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首页> 外文期刊>Environmental Health: A Global Access Science Source >Urinary bisphenol A concentrations in girls from rural and urban Egypt: a pilot study
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Urinary bisphenol A concentrations in girls from rural and urban Egypt: a pilot study

机译：埃及农村和城市女孩尿中双酚A含量的初步研究

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Background Exposure to endocrine active compounds, including bisphenol A (BPA), remains poorly characterized in developing countries despite the fact that behavioral practices related to westernization have the potential to influence exposure. BPA is a high production volume chemical that has been associated with metabolic dysfunction as well as behavioral and developmental effects in people, including children. In this pilot study, we evaluate BPA exposure and assess likely pathways of exposure among girls from urban and rural Egypt. Methods We measured urinary concentrations of total (free plus conjugated) species of BPA in spot samples in urban (N = 30) and rural (N = 30) Egyptian girls, and compared these concentrations to preexisting data from age-matched American girls (N = 47) from the U.S. National Health and Nutrition Examination Survey (NHANES). We also collected anthropometric and questionnaire data regarding food storage behaviors to assess potential routes of exposure. Results Urban and rural Egyptian girls exhibited similar concentrations of urinary total BPA, with median unadjusted values of 1.00 and 0.60 ng/mL, respectively. Concentrations of urinary BPA in this group of Egyptian girls (median unadjusted: 0.70 ng/mL) were significantly lower compared to age-matched American girls (median unadjusted: 2.60 ng/mL) according to NHANES 2009-2010 data. Reported storage of food in plastic containers was a significant predictor of increasing concentrations of urinary BPA. Conclusions Despite the relatively low urinary BPA concentrations within this Egyptian cohort, the significant association between food storage behaviors and increasing urinary BPA concentration highlights the need to understand food and consumer product patterns that may be closing the gap between urban and rural lifestyles.
机译：背景技术尽管与西化有关的行为习惯有可能影响暴露，但发展中国家对内分泌活性化合物（包括双酚A（BPA））的暴露仍知之甚少。 BPA是一种高产量化学品，与代谢功能障碍以及包括儿童在内的人的行为和发育影响有关。在这项初步研究中，我们评估了BPA暴露，并评估了埃及城市和农村女孩的BPA暴露可能途径。方法我们测量了城市（N = 30）和农村（N = 30）埃及女孩的现场样本中BPA总（游离和共轭）物种的尿液浓度，并将这些浓度与年龄匹配的美国女孩（N = 47）来自美国国家健康与营养检查调查（NHANES）。我们还收集了有关食物储存行为的人体测量学和问卷数据，以评估潜在的暴露途径。结果城市和农村埃及女孩的尿液总BPA浓度相似，未经调整的中位数分别为1.00和0.60 ng / mL。根据NHANES 2009-2010数据，与年龄相匹配的美国女孩（未调整中位数：2.60 ng / mL）相比，这一组埃及女孩（未调整中位数：0.70 ng / mL）中尿BPA的浓度显着降低。据报道，将食物储存在塑料容器中是尿液BPA浓度增加的重要预测指标。结论尽管该埃及人队列中的尿液BPA浓度相对较低，但食物存储行为与尿液BPA浓度增加之间的显着联系强调了需要了解可能缩小城市与乡村生活方式之间差距的食品和消费产品模式。

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