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首页> 外文期刊>Epilepsy currents >Complete the Following Statement: Industry-Sponsored Antiepileptic Drug Pregnancy Registries Provide Information that is Beneficial to:: Patients ? Doctors ? The Sponsor ? All of the Above ? None of the Above ? Cannot Respond Due to Risk of COI
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Complete the Following Statement: Industry-Sponsored Antiepileptic Drug Pregnancy Registries Provide Information that is Beneficial to:: Patients ? Doctors ? The Sponsor ? All of the Above ? None of the Above ? Cannot Respond Due to Risk of COI

机译：填写以下声明：行业赞助的抗癫痫药怀孕注册中心提供的信息对以下患者有利：医生？赞助商？上述所有的 ？以上都不是 ？由于存在COI风险而无法响应

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GSK has positioned lamotrigine as an AED to consider when treating women of childbearing potential. In spite of the challenges around the variable clearance of lamotrigine with exogenous hormones such as oral contraceptives and with endogenous hormones during pregnancy, the GSK pregnancy registry and other registries bear out a low frequency of MCMs with use during pregnancy. This is good and useful news for patients, healthcare providers, and for GSK. Did we need an industry-sponsored pregnancy registry to find this out? These findings would have eventually been reported in other registries. However, putting aside the marketing strategy, this registry was established before any of the academic registries, which, outside of the national health registries are supported by industry funding in any case. Even the Danish database study cited herein was supported in part by Lundbeck. The GSK registry was established to answer a dire clinical question, provided early reports on frequencies of malformations, was not more biased than other registries, and of course helped to market Lamictal. Best answer D.
机译：GSK将拉莫三嗪定位为AED，在治疗有生育能力的女性时要考虑使用。尽管围绕拉莫三嗪与外源性激素（例如口服避孕药）和怀孕期间的内源性激素的清除率存在不同的挑战，但GSK怀孕登记簿和其他登记簿证明在怀孕期间使用MCM的频率较低。对于患者，医疗保健提供者和葛兰素史克来说，这是个好消息。我们是否需要行业赞助的怀孕登记系统来找到答案？这些发现最终将在其他注册表中报告。但是，撇开市场营销策略，该注册中心是在任何学术注册机构之前建立的，在任何情况下，国家卫生注册机构之外的机构都需要行业资金的支持。甚至本文引用的丹麦数据库研究也得到了伦贝克的部分支持。建立GSK注册表是为了回答一个严峻的临床问题，它提供了有关畸形频率的早期报告，并没有比其他注册表更偏颇，当然也有助于推销Lamictal。最佳答案D.

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