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首页> 外文期刊>Epigenetics & Chromatin >Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region
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Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region

机译：哥斯达黎加长寿地区的差异DNA甲基化和淋巴细胞比例

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Background The Nicoya Peninsula in Costa Rica has one of the highest old-age life expectancies in the world, but the underlying biological mechanisms of this longevity are not well understood. As DNA methylation is hypothesized to be a component of biological aging, we focused on this malleable epigenetic mark to determine its association with current residence in Nicoya versus elsewhere in Costa Rica. Examining a population’s unique DNA methylation pattern allows us to differentiate hallmarks of longevity from individual stochastic variation. These differences may be characteristic of a combination of social, biological, and environmental contexts. Methods In a cross-sectional subsample of the Costa Rican Longevity and Healthy Aging Study, we compared whole blood DNA methylation profiles of residents from Nicoya ( n =?48) and non-Nicoya (other Costa Rican regions, n =?47) using the Infinium HumanMethylation450 microarray. Results We observed a number of differences that may be markers of delayed aging, such as bioinformatically derived differential CD8+ T cell proportions. Additionally, both site- and region-specific analyses revealed DNA methylation patterns unique to Nicoyans. We also observed lower overall variability in DNA methylation in the Nicoyan population, another hallmark of younger biological age. Conclusions Nicoyans represent an interesting group of individuals who may possess unique immune cell proportions as well as distinct differences in their epigenome, at the level of DNA methylation.
机译：背景哥斯达黎加的尼科亚半岛是世界上预期寿命最高的国家之一，但这种长寿的潜在生物学机制尚未得到很好的理解。由于DNA甲基化被认为是生物衰老的组成部分，因此我们重点研究了可延展的表观遗传标记，以确定其与尼古亚和哥斯达黎加其他地区目前居住地的关联。通过研究人群独特的DNA甲基化模式，我们可以将长寿的标志与个人的随机变化区分开。这些差异可能是社会，生物学和环境背景相结合的特征。方法在《哥斯达黎加人长寿和健康衰老研究》的横断面子样本中，我们使用以下方法比较了来自尼科亚（n =？48）和非尼古亚（其他哥斯达黎加地区，n =？47）居民的全血DNA甲基化谱。 Infinium HumanMethylation450微阵列。结果我们观察到许多差异可能是延迟衰老的标志，例如生物信息学衍生的差异CD8 + T细胞比例。此外，位点和区域特异性分析都揭示了尼古里亚人独有的DNA甲基化模式。我们还观察到Nicoyan人群中DNA甲基化的总体变异性较低，这是年轻生物时代的另一个标志。结论尼古拉人是一组有趣的个体，在DNA甲基化水平上，它们可能具有独特的免疫细胞比例以及其表观基因组的明显差异。

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