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首页> 外文期刊>Environmental Epigenetics >Bugs in the program: can pregnancy drugs and smoking disturb molecular reprogramming of the fetal germline, increasing heritable risk for autism and neurodevelopmental disorders?
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Bugs in the program: can pregnancy drugs and smoking disturb molecular reprogramming of the fetal germline, increasing heritable risk for autism and neurodevelopmental disorders?

机译：程序中的错误：怀孕药物和吸烟是否会干扰胎儿生殖细胞的分子重编程，增加自闭症和神经发育障碍的遗传风险？

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In a seeming paradox, the prevalence of autism spectrum disorder (ASD) has surged, while at the same time research has pointed to the strong heritability of this neurodevelopmental pathology. Here an autism research philanthropist suggests a biological phenomenon of exogenously induced ‘gamete disruption’ that could reconcile these seemingly contradictory observations. Mining information from her own family history and that of her fellow autism parents, while also engaging with the scientific community, she proposes that a subset of the autisms may be rooted in a variety of molecular glitches in parental gametes induced by certain acute exposures during the parents’ own fetal or neonatal development. These exposures include but are not limited to synthetic hormone drugs, tobacco, and general anesthesia. Consistent with this hypothesis, animal models have demonstrated adverse neurobehavioral outcomes in grandoffspring of gestating dams exposed to hormone-disrupting compounds, tobacco components, and general anesthesia. A recent epidemiological study showed a link between grandmaternal smoking and risk for ASD in grandoffspring through the maternal line. Given the urgency of the autism crisis, combined with the biological plausibility of this mostly unexplored paradigm, the writer contends that questions of nongenetic inheritance should be a priority in autism research.
机译：在一个自相矛盾的现象中，自闭症谱系障碍（ASD）的患病率激增，而同时研究也指出这种神经发育病理学具有很强的遗传力。一位自闭症研究慈善家在这里提出了一种外源性“配子破坏”的生物学现象，这种现象可以调和这些看似矛盾的观察结果。她还从自己的家族史和自闭症父母的同伴中获取信息，同时也与科学界互动，她建议，自闭症的一个子集可能根源于父母在配子体内某些急性暴露引起的配子分子故障。父母自己的胎儿或新生儿发育。这些暴露包括但不限于合成激素药物，烟草和全身麻醉。与该假设一致，动物模型在暴露于激素破坏性化合物，烟草成分和全身麻醉的妊娠大坝的后代中显示出不良的神经行为结果。最近的一项流行病学研究表明，通过母系，祖母吸烟与祖孙中的ASD风险之间存在联系。鉴于自闭症危机的紧迫性，再加上这种尚未被广泛探索的范式的生物学可行性，作者认为，非遗传遗传问题应成为自闭症研究的优先领域。

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