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首页> 外文期刊>Epilepsy & Behavior Case Reports >Autoimmune encephalopathy and drug refractory seizures with the presence of two autoantibodies specific for the neuronal cell surface
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Autoimmune encephalopathy and drug refractory seizures with the presence of two autoantibodies specific for the neuronal cell surface

机译：自身免疫性脑病和药物难治性癫痫发作，同时存在两种对神经元细胞表面有特异性的自身抗体

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Background An increasing number of autoantibodies are being described in epilepsy and other seizure-related disorders. A pathogenic role of autoantibodies in epilepsy has been suggested based on observations of the efficacy of immunotherapy. Objective This study aimed to report a new case of autoimmune-mediated encephalopathy and seizures caused by autoantibodies to voltage-gated potassium channels (VGKCs) and voltage-gated calcium channels (VGCCs) (P/Q-type) and the response to immunotherapy. Design This study follows a case report design. Setting This study was conducted in a tertiary care center. Patients Our patient was an eighteen-year-old female with new-onset encephalopathy and refractory seizures. Intervention Our patient was treated for five days with intravenous methylprednisolone (IVMP) and intravenous immunoglobulin (IVIG). Results After treatment with IVMP and IVIG, our patient showed significant clinical improvement and did not exhibit any seizures during the one-month follow-up period. Conclusions Here, we report a rare case of an autoimmune encephalopathy and seizures associated with the presence of two surface neuronal autoantibodies. This report highlights the importance of early diagnosis of autoimmune epilepsy, as early immunomodulating treatments improve the outcome.
机译：背景技术在癫痫和其他与癫痫发作有关的疾病中描述了越来越多的自身抗体。基于对免疫疗法功效的观察，已经提出了自身抗体在癫痫中的致病作用。目的本研究旨在报告由电压门控钾通道（VGKCs）和电压门控钙通道（VGCCs）（P / Q型）自身抗体引起的自身免疫介导的脑病和癫痫发作的新病例，以及对免疫疗法的反应。设计本研究遵循病例报告设计。设置本研究在三级护理中心进行。患者我们的患者是一名18岁的女性，患有新发性脑病和难治性癫痫发作。干预措施我们的患者接受了静脉甲基强的松龙（IVMP）和静脉免疫球蛋白（IVIG）的治疗，为期5天。结果经IVMP和IVIG治疗后，我们的患者表现出明显的临床改善，并且在一个月的随访期内未出现任何癫痫发作。结论在这里，我们报道了一种罕见的自身免疫性脑病和与两种表面神经元自身抗体有关的癫痫发作。该报告强调了早期诊断自身免疫性癫痫的重要性，因为早期免疫调节治疗可改善预后。

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