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首页> 外文期刊>Epidemiology Research International. >Factors Associated with a Poor Treatment Outcome among Children Treated for Malaria in Ibadan, Southwest Nigeria
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Factors Associated with a Poor Treatment Outcome among Children Treated for Malaria in Ibadan, Southwest Nigeria

机译：尼日利亚西南部伊巴丹接受疟疾治疗的儿童中治疗结果差的相关因素

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We present data on factors associated with poor treatment outcome (death or recovery with a neurological complication) among children treated for malaria in Ibadan, Nigeria. A total of 2468 children (1532 with uncomplicated and 936 with severe malaria) were recruited from three government facilities. History was obtained from caregivers and malarial parasite test was carried out on each child. About 76.0% of caregivers had instituted home treatment. Following treatment, 2207 (89.5%) children recovered without complications, 9.1% recovered with neurological complications, and 1.4% died. The possibility of poor treatment outcome increased with decreasing child’s age (P<0.0001). A statistically significant proportion of children with pallor, jaundice, hepatomegaly, splenomegaly, respiratory distress, and severe anaemia had poor treatment outcome. Following logistic regression, child’s age < 12 months compared to older age groups (O.R = 5.99, 95% C.I = 1.15–31.15, andP=0.033) and loss of consciousness (O.R = 4.55, 95% CI = 1.72–12.08, andP=0.002) was significantly associated with poor treatment outcome. We recommend interventions to improve caregivers’ awareness on the importance of seeking medical care early. This will enhance early diagnosis and treatment and reduce the likelihood of complications that lead to poor treatment outcomes.
机译：我们提供了与尼日利亚伊巴丹接受疟疾治疗的儿童中治疗效果差（死亡或神经系统并发症恢复）相关的因素数据。从三个政府机构招募了2468名儿童（1532名无并发症儿童和936名严重疟疾）。从看护者那里获得病史，并对每个孩子进行疟疾寄生虫测试。大约76.0％的护理人员已开始家庭治疗。治疗后，有2207名儿童（89.5％）康复无并发症，有9.1％的神经系统并发症康复，有1.4％死亡。随着儿童年龄的降低，治疗效果差的可能性增加（P <0.0001）。具有统计学意义的苍白，黄疸，肝肿大，脾肿大，呼吸窘迫和严重贫血的儿童治疗效果差。经逻辑回归后，与较大年龄组相比，儿童的年龄<12个月（OR = 5.99，95％CI = 1.15–31.15，P = 0.033）和失去知觉（OR = 4.55，95％CI = 1.72–12.08，P = 0.002）与治疗效果差显着相关。我们建议采取干预措施，以提高护理人员对及早就医的重要性的认识。这将加强早期诊断和治疗，并减少导致不良治疗结果的并发症发生的可能性。

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