Sudden Unexpected Death in Dravet Syndrome

Jennifer Kearney

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Sudden Unexpected Death in Dravet Syndrome

机译：Dravet综合征突然死亡

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Although the precise mechanism has yet to be defined, the key finding of this study is the observation that SUDEP risk in mice with Nav1.1 deletion is correlated with profound ictal bradycardia and that limiting the duration of bradycardia via parasympathetic modulation improved survival. This suggests that implantable pacemakers may be an effective treatment for preventing SUDEP in some Dravet syndrome patients, although defining those at particularly high risk remains a significant challenge.

机译：尽管尚未确定确切的机制，但这项研究的主要发现是观察到，Nav1.1缺失的小鼠的SUDEP风险与深刻的发作性心动过缓有关，并且通过副交感神经调节来限制心动过缓的持续时间可改善存活率。这表明，在某些Dravet综合征患者中，植入式起搏器可能是预防SUDEP的有效方法，尽管确定高危人群仍是一项重大挑战。

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《Epilepsy currents》 |2013年第6期|共页
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Jennifer Kearney;
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中图分类神经病学与精神病学;
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1. Two autopsy cases of sudden unexpected death from Dravet syndrome with novel de novo SCN1A variants [J] . Brain & Development . 2020,第2期

机译：具有新型德诺伊州SCN1A变体的DRAVET综合征突然意外死亡的两种尸检病例
2. Sudden unexpected death in Dravet syndrome [J] . KearneyJ. Epilepsy currents . 2013,第6期

机译：Dravet综合征突然猝死
3. Effect of vagus nerve stimulation in an adult patient with dravet syndrome: Contribution to sudden unexpected death in epilepsy risk reduction? [J] . SpatolaM., JeannetP.-Y., PolloC., European neurology . 2013,第2期

机译：迷走神经刺激对成年患者dravet综合征的影响：导致癫痫风险降低的突然意外死亡的原因？
4. GC-MS/MS Characterization of EDCs in Human Tissues for Environmental Risk Factors Assessment in the Sudden Infant and Sudden Intrauterine Death Syndromes. [C] . Pierangela Palma, Veronica Termopoli, Giorgio Famiglini, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：突发婴儿环境风险因素评估的人体组织中EDC的GC-MS / MS表征，术后宫内死亡综合征。
5. A Black Man's Grief: The Lived Experience of the Sudden and Unexpected Death of a Child [D] . Dean, Vanessa. 2021

机译：一个黑人的悲伤：孩子突然和意外死亡的生活经历
6. Sudden Unexpected Death in Dravet Syndrome [O] . Jennifer Kearney 2013

机译：Dravet综合征突然死亡
7. Effect of vagus nerve stimulation in an adult patient with Dravet syndrome: contribution to sudden unexpected death in epilepsy risk reduction? [O] . Spatola, Marianna, Jeannet, Pierre-Yves, Pollo, Claudio, 2013

机译：迷走神经刺激对成年Dravet综合征患者的影响：导致癫痫风险降低的突然意外死亡的原因？
8. Guidelines for Death Scene Investigation of Sudden, Unexplained Infant Deaths:211 Recommendations of the Interagency Panel on Sudden Infant Death Syndrome. 211 Morbidity and Mortality Weekly Report, Vol. 45, No. RR-10, June 21, 1996 [R] . Iyasu, S., Rowley, D. L., Hanzlick, R. L., 1996

机译：关于突发，原因不明的婴儿死亡的死亡现场调查指南：211关于突发婴儿死亡综合症的机构间小组的建议。 211发病率和死亡率周报，第一卷。 45，第RR-10号，1996年6月21日

Sudden Unexpected Death in Dravet Syndrome

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